ADVERSE PREGNANCY OUTCOME ASSOCIATED FREE ALPHA FETOPROTEIN, FREE β HUMAN CHORIONIC GONADOTROPIN OF PREGNANT WOMEN IN THE SECOND TRIMESTER AND THEIR AGE
Objective To investigate the association of serum levels of β HCG,AFP and age of pregnant women in the second trimester with adverse pregnancy outcomes (APO).Methods From March 2012 to March 2014,a total of 1 648 cases of pregnant women in the second trimester underwent serological screening in our hospital,their pregnancy outcomes were followed up.According to the level of serum markers,the pregnant women were divided into the following groups:elevated free β-HCG group (β-HCG ≥ 2.0 MOM),elevated AFP group (AFP ≥ 2.0 MOM),free β HCG and AFP increased simultaneously group ([-HCG and AFP≥2.0 MOM),and normal group (normal serum markers).The incidence of APO between elevated-marker groups and normal group was compared.Taking 35 years old as boundary,the incidence of APO,between those ＜35 years old and those ≥35 years old,was compared;setting β-HCG≥2.0 MOM and/or AFP≥2.0 MOM as elevating group,the APO between different age groups and normal group was compared.Results The differences in the incidence of gestational hypertension (GH) and fetal distress (FD) between the β HCG≥2.0 MOM group and the normal group was statistically significant (x2 =11.229,44.653;P＜0.05).The difference in incidence of GH In the AFP≥2.0 MOM group and the normal group was significant (x2 =37.981,P＜0.05).The difference in incidence of placental abruption (PA) between the β-HCG and AFP≥2.0 MOM group and normal group was statistically significant (x2-18.866,P＜0.05).The differences in GDM,GH,and premature delivery between the ≥35-year-old group and ＜35-year-old group were significant (x2-12.994 18.713,P＜0.05).The differences in GH,FD,and PA between elevated group In ＜35-year-old group and normal group were significant (x2 =5.064-33.900,P＜0.05).The differences in incidence of GH,FD and PA between the ≥35-year-old of the elevated group and normal group were not statistically significant (P＞0.05).Conclusion Elevation of the serum level of free β-HCG and AFP in the second trimester is closely related with the adverse pregnancy outcomes,combining maternal age,it has certain clinical significance in predicting the final result of the pregnancy.
NETL
NSTL
万方数据
维普
