CORRELATION OF ELWI WITH ITBI AND RESPIRATORY FUNCTION PARAMETERS IN PATIENTS WITH ACUTE EXACERBATION OF COPD AND RESPIRATORY FAILURE
Objective To investigate the relationship of extravascular lung water index (ELWI) monitored by pulse-induced contour cardiac output (PiCCO) with intrathoracic blood volume index (ITBI) and respiratory function parameters in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) and respiratory failure.Methods A retrospective analysis was performed in 77 patients with AECOPD and respiratory failure who were admitted to the intensive care unit in our hospital from June 2013 to December 2016.All patients were monitored by PiCCO and subjected to blood gas analysis to investigate the changes in each index after treatment and the correlation of ELWI with ITBI,partial pressure of oxygen (PaO2)/fraction of inspired oxygen (FiO2) ratio (PaO2/FiO2),respiratory rate (RR),static lung compliance (Cs),and so on.Results At 72 hours after treatment,6 patients died,with a mortality rate of 7.79％.At 24,48,and 72 hours after treatment,ELWI,ITBI,RR,and partial pressure of carbon dioxide (PaCO2) gradually decreased,and PaO2/FiO2,Cs,PaO2,and p H gradually increased (F =11.945-31.872,P ＜0.05).Multiple regression analysis showed that ELWI was negatively correlated with PaO2/FiO2,Cs,PaO2,and pH (B=-0.517--0.268,P＜0.05) and positively correlated with PaCO2 (B=0.338,P＜0.05).Conclusion In patients with AECOPD and respiratory failure,ELWI is significantly correlated with ITBI and respiratory function parameters.It is of great significance for the patients to perform fluid management according to ELWI measured by PiCCO.
pulmonary disease, chronic obstructiverespiratory insufficiencycardiac outputextravascular lung water indexintrathoracic blood volume indexrespiratory function tests
NETL
NSTL
万方数据
维普
