EFFICACY OF DIFFERENT HEMOPERFUSION PROCEDURES COMBINED WITH CONTINUOUS RENAL REPLACEMENT THERAPY IN PATIENTS WITH ACUTE SEVERE ORGANOPHOSPHATE POISONING
Objective To determine the therapeutic efficacy of different hemoperfusion procedures combined with continuous renal replacement therapy (CRRT) in the treatment of acute severe organophosphate poisoning (ASOPP) patients.Methods Sixty-three ASOPP patients admitted to our hospital from December 2014 to February 2017 were divided into control group and strengthened group based on the different hemoperfusion procedures they received.The two groups of patients were given different hemoperfusion procedures combined with CRRT in addition to the conventional treatment,and the clinical outcome was compared between the two groups.Results The total amounts of atropine,penehyclidine hydrochloride,and pralidoxime chloride used,as well as the duration of mechanical ventilation and hospital stay,were significantly reduced in the strengthened group than in the control group (t =2.479-5.618,P ＜ 0.01).After 3 and 5 days of treatment,cholinesterase activity was significantly higher in the strengthened group than in the control group (t =16.315,22.747;P＜0.05).Furthermore,the incidence of complications including intermediate syndrome,rebound,and multiple organ dysfunction syndrome,as well as mortality,were also signifi cantly lower in the strengthened group than in the control group (x2 =4.399 5.611,P＜0.05).Conclusion ASOPP patients treated with the strengthened hemoperfusion procedure have enhanced treatment outcome than those with the conventional hemoperfusion procedure.Therefore,the strengthened hemoperfusion procedure holds promise for clinical application.
NETL
NSTL
万方数据
维普
