AN ANALYSIS OF PATHOGENIC BACTERIA OF VENTILATOR-ASSOCIATED PNEUMONIA IN LATE PRETERM INFANTS WITH RESPIRATORY DISTRESS SYNDROME
Objective To instigate the distribution and drug resistance of pathogenic bacteria of ventilator associated pneumonia (VAP) in late preterm infants with respiratory distress syndrome (RDS) in neonatal intensive care unit (NICU),and to provide a reference for antibiotic selection.Methods A retrospective analysis was performed in 38 late preterm infants with RDS who developed VAP during mechanical ventilation in the NICU of Qingdao Women and Children Hospital from January 2013 to De cember 2015.The tracheal secretion culture and drug sensitivity test were performed in all patients.Results Of all the 38 pa tients,30 (78.95%) had a positive bacterial culture.A total of 40 strains of pathogenic bacteria were isolated,including 3 Grampositive strains (7.5 %) and 37 Gram-negative strains (92.5 %).Klebsiella pneumoniae,Pseudomonas aeruginosa,and Acinetobacter baumannii were the three main pathogenic bacteria.There were 12 strains of extended-spectrum β lactamases (ESBLs)-producing Klebsiella pneumoniae (60%) and the ESBLs-producing strains had a higher drug resistance than the non-ESBLs producing strains.There were no ESBLs producing Pseudomonas aeruginosa and Acinetobacter baumannii.The three main pathogenic bacteria had a high resistance to cephalosporins and were sensitive to imipenem,piperacillin tazobactam,and ciprofloxacin.Conclusion Gram-negative bacteria are main pathogenic bacteria of VAP in late preterm infants with RDS and they are extensively resistant to common antibiotics.