EFFECT OF SALVIAE MILTIORRHIZAE AND LIGUSTRAZINE HYDROCHLORIDE INJECTION ON PLASMA LEVEL OF LYSOPHOSPHATIDIC ACID IN PATIENTS WITH ACUTE CEREBRAL INFARTION
Objective To investigate the effect of Salviae miltiorrhizae and ligustrazine hydrochloride injection on the plasma level of lysophosphatidic acid (LPA) in patients with acute cerebral infarction.Methods A total of 80 patients with acute cerebral infarction admitted to the Department of Neurology in the Affiliated Hospital of Qingdao University were included in this study.These patients were randomly divided into observation group and control group at 40 patients per group.While both groups received the conventional treatment and symptomatic treatment for acute cerebral infarction,the observation group also received a daily injection of 10 mL Salviae miltiorrhizae and ligustrazine hydrochloride solution.Treatment efficacy and the plasma LPA level were compared between the two groups.Results Plasma LPA level in both groups was significantly reduced after treatment (t =236.60,352.16;P ＜0.01),and the plasma LPA level in the observation group was significantly lower than that in the control group (t =5.95,P＜0.05).Furthermore,treatment efficacy was significantly better in the observation group than in the control group (H=242.20,P＜0.01).Conclusion Salviae miltiorrhizae and ligustrazine hydrochloride injection can significantly enhance treatment efficacy and reduce plasma LPA level in patients with acute cerebal infarction.
Salviae miltiorrhizae and ligustrazine hydrochloride injectionbrain infarctionlysophospholipidstreatment outcome
NETL
NSTL
万方数据
维普
