EFFECT OF PERIOPERATIVE INTRAVENOUS INJECTION OF LIDOCAINE ON LYMPHOCYTE IMMUNE FUNCTION IN PATIENTS WITH CERVICAL CANCER
Objective To investigate the effect of perioperative intravenous infusion of lidocaine on immune function of lymphocytes in peripheral venous blood in patients undergoing surgery for cervical cancer.Methods A total of 30 patients who underwent radical surgery for cervical cancer were randomized into control group (group C) and lidocaine group (group L).The patients in group L were given intravenous injection of lidocaine 1.5 mg/kg at 15 minutes before induction of anesthesia,followed by intravenous infusion of lidocaine 1.5 mg · kg-1 · h-1 using a micro-pump till the end of surgery,and those in group C were given an equal volume of normal saline.A total of 10 mL peripheral venous blood was collected at 48 hours before surgery,immediately after surgery,and at 48 hours after surgery,and plasma and lymphocytes were isolated.Flow cytometry was used to measure the apoptosis rate of peripheral lymphocytes,CCK-8 was used to measure the proliferation of peripheral lymphocytes,and ELISA was used to measure the plasma levels of interferon gamma (IFN-γ) and interleukin-4 (IL-4).Results Compared with group C,group L had a significant increase in the proliferative capacity of lymphocytes immediately and at 48 hours after surgery (F =4.32,4.65;P＜0.05).At 48 hours after surgery,group L had significantly higher plasma level of IFN-γ and IFN-γ/IL-4 ratio than group C (F=7.581,5.273;P＜0.05).Conclusion Perioperative intravenous infusion of lidocaine exerts a protective effect on the immune function of lymphocytes in patients with cervical cancer undergoing radical surgery and may bring benefits to postoperative rehabilitation.
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万方数据
维普
