长春瑞滨并顺铂治疗晚期NSCLC病人骨髓抑制发生时间与近期疗效相关性
ASSOCIATION BETWEEN TIME OF ONSET OF MYELOSUPPRESSION AND SHORT-TERM RESPONSE IN PATIENTS WITH ADVANCED NON-SMALL CELL LUNG CANCER TREATED WITH VINORELBINE AND CISPLATIN
刘海新 1毕迎惠 1郭成业 1张亚琨2
作者信息
- 1. 青岛市市立医院(集团)西院区肿瘤一科,山东青岛266011
- 2. 青岛市市立医院(集团)东院区肿瘤科,山东青岛266011
- 折叠
摘要
目的 探讨接受长春瑞滨并顺铂方案(NP方案)一线化疗的晚期非小细胞肺癌(NSCLC)病人骨髓抑制发生时间与近期疗效的关系.方法 共收集晚期NSCLC病人138例,均接受至少2周期NP方案一线化疗,按骨髓抑制发生时间分为早期骨髓抑制组(第1～2周期化疗期间发生骨髓抑制)和非早期骨髓抑制组(第3～6周期化疗期间发生骨髓抑制或化疗期间无骨髓抑制),分析其与近期化疗效果的关系.结果 早期骨髓抑制组、非早期骨髓抑制组治疗客观有效率分别为71.8％(69/96)、35.7％,两组比较差异有显著性(x2=16.04,P＜0.05);两组肿瘤控制率分别为81.3％、64.3％,两组比较差异无显著性(P＞0.05).结论 对于接受NP方案一线化疗的晚期NSCLC病人,早期发生骨髓抑制是影响近期化疗效果的有利因素,对化疗效果具有一定的预测价值.
Abstract
Objective To investigate the association between time of onset of myelosuppression and short-term response in patients with advanced non-small cell lung cancer (NSCLC) treated with vinorelbine and cisplatin (NP regimen).Methods A total of 138 patients with advanced NSCLC who received at least two cycles of first-line chemotherapy with NP regimen were enrolled,and according to the time of onset of myelosuppression,these patients were divided into early myelosuppression group (myelosuppression occurred during the 1-2 cycles of chemotherapy) and non-early myelosuppression group (myelosuppression occurred during the 3-6 cycles of chemotherapy or no myelosuppression occurred during chemotherapy).The association between time of onset of myelosuppression and short-term response was analyzed.Results The objective response rate was 71.8％ (69/96) in the early myelosuppression group and 35.7％ in the non-early myelosuppression group,and there was a significant difference between the two groups (x2 =16.04,P＜0.05).There was no significant difference in tumor control rate between the two groups (81.3％ vs 64.3％,P＞0.05).Conclusion In patients with advanced NSCLC who receive the first-line chemotherapy with NP regimen,early onset of myelosuppression is a favorable factor for short-term response to chemotherapy and has a certain value in predicting the efficacy of chemotherapy.
关键词
癌,非小细胞肺/药物疗法/骨髓抑制/治疗结果Key words
carcinoma, non-small-cell lung/drug therapy/hematological toxicity/treatment outcome引用本文复制引用
出版年
2017
NETL
NSTL
维普
万方数据