ASSOCIATION BETWEEN TIME OF ONSET OF MYELOSUPPRESSION AND SHORT-TERM RESPONSE IN PATIENTS WITH ADVANCED NON-SMALL CELL LUNG CANCER TREATED WITH VINORELBINE AND CISPLATIN
Objective To investigate the association between time of onset of myelosuppression and short-term response in patients with advanced non-small cell lung cancer (NSCLC) treated with vinorelbine and cisplatin (NP regimen).Methods A total of 138 patients with advanced NSCLC who received at least two cycles of first-line chemotherapy with NP regimen were enrolled,and according to the time of onset of myelosuppression,these patients were divided into early myelosuppression group (myelosuppression occurred during the 1-2 cycles of chemotherapy) and non-early myelosuppression group (myelosuppression occurred during the 3-6 cycles of chemotherapy or no myelosuppression occurred during chemotherapy).The association between time of onset of myelosuppression and short-term response was analyzed.Results The objective response rate was 71.8% (69/96) in the early myelosuppression group and 35.7% in the non-early myelosuppression group,and there was a significant difference between the two groups (x2 =16.04,P<0.05).There was no significant difference in tumor control rate between the two groups (81.3% vs 64.3%,P>0.05).Conclusion In patients with advanced NSCLC who receive the first-line chemotherapy with NP regimen,early onset of myelosuppression is a favorable factor for short-term response to chemotherapy and has a certain value in predicting the efficacy of chemotherapy.