THE ROLE OF PI3K/AKT SIGNALING PATHWAY DURING EPITHELIAL-MESENCHYMAL TRANSITION IN ENDOMETRIAL ADENOCARCINOMA
Objective To examine the role of PI3K/Akt signaling pathway in the process of epithelial-mesenchymal transition (EMT) in endometrial adenocarcinoma.Methods The protein expression of p-Akt,E-cadherin,and vimentin in 12 normal endometrium tissues,16 endometrium hyperplasia tissues,and 32 endometrial adenocarcinoma tissues was determined by PV-6000 immunohistochemistry.The relationship between the three proteins and each clinicopathological parameter was analyzed.Results The rates of p-Akt,E-cadherin,and vimentin expression were significantly different between the three groups (x2 =13.91 19.28,P＜0.05).The expression of p-Akt in endometrial carcinoma tissues was associated with pathological stage and lymph node metastasis (P =0.041 and 0.047,respectively),but not with the degree of myometrial invasion and histological grade (P =0.676 and 0.070,respectively).The expression of E-cadherin was associated with pathological stage,degree of myometrial invasion,and lymph node metastasis (P =0.008,0.029,and 0.026,respectively),but not with histological grade (P =0.640).The expression of vimentin was associated with pathological stage and lymph node metastasis (P =0.019 and 0.012,respectively),but not with degree of myometrial invasion and histological grade (P =0.647 and 0.648,respectively).In addition,the expression of pAkt was positively correlated with vimentin expression (r =0.462,P ＜0.05),and was negatively correlated with E-cadherin expression in endometrial carcinoma tissues (r=-0.567,P＜0.05).Conclusion The PI3K/Akt signaling pathway may be involved in tumor invasion and metastasis through mediating the EMT of endometrial adenocarcinoma.
NETL
NSTL
万方数据
维普
