ANTIBIOTIC RESISTANCE OF STAPHYLOCOCCUS AUREUS IN A HOSPITAL IN SHANDONG, CHINA, FROM 2011 TO 2015
Objective To investigate the distribution,epidemiological features,and antibiotic resistance of Staphylococcus aureus (SAU) in one hospital in Shandong,China,from 2011 to 2015,and to provide a reference for rational use of antibiotics in clinical practice.Methods A total of 2 117 SAU strains isolated from various types of clinical specimens in our hospital from 2011 to 2015 were collected (the strains from the same patient were excluded).VITEK MS mass spectrometer and VITEK2 Compact automatic microbial analysis system were used for strain identification,the K-B method and VITEK2 Compact automatic microbial analysis system were used for drug sensitivity test,and WHONET 5.6 software was used for data analysis.Results Among the 2 117 SAU strains,894 were isolated from wound secretions,843 were isolated from sputum,and 126 were isolated from pleuroperitoneal fluid.Department of General Surgery had the highest detection rate (421 strains),followed by the intensive care unit (ICU) (223 strains) and Department of Burns and Plastic Surgery (215 strains).There were 588 strains of methicillin-resistant Staphylococcus aureus (MRSA) with a detection rate of 27.78％,which were commonly seen in sputum (248),wound secretions (235),and pleuroperitoneal fluid (45);Department of Burns and Plastic Surgery (122 strains) had the highest detection rate of MRSA,followed by Department of the ICU (78 strains) and Thoracic Surgery (38 strains).SAU had the highest resistance rate to penicillin G (92.6 ％),followed by erythromycin (80.8 ％).No strains were found resistant to vancomycin,teicoplanin,or linezolid.Conclusion The major routes of SAU infection are respiratory tract and skin soft tissue,and patients in Department of Surgery and the ICU are at a high risk for infection.Among SAU strains isolated from some clinical departments,MRSA have a high resistance rate,and clinical departments should strengthen the monitoring of MRSA resistance and use antibiotics rationally.Hospital infection management department should distribute the work with reference to related data,in order to avoid nosocomial infection.
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