CORRELATION BETWEEN LEVELS OF NEUTROPHIL EXTRACELLULAR TRAPS AND LOWER EXTREMITY DEEP VENOUS THROMBOSIS AFTER TOTAL HIP ARTHROPLASTY
Objective To investigate the correlation between the levels of neutrophil extracellular traps (NETs) and lower extremity deep venous thrombosis (DVT) after total hip arthroplasty.Methods A total of 113 patients who underwent total hip arthroplasty were divided into DVT group (n =31) and non-DVT group (n =82) according to whether they had DVT or not.Their clinical data and perioperative data were collected.At 24 h before surgery and at 24 h,72 h,and 5 d after surgery,the serum levels of dsDNA/NETs were measured using PicoGreen fluorescent dye.The values of serum levels of dsDNA/NETs at different postoperative points in predicting lower extremity DVT after surgery were analyzed using the receiver operating characteristic (ROC) curve.Results The DVT group had significantly higher serum levels of dsDNA/NETs at 24 and 72 h after surgery than the non-DVT group (t =4.002,5.993;P＜0.05).The serum levels of dsDNA/NETs in the two groups at 24 and 72 h after surgery were significantly higher than those at 24 h before surgery (F=27.023,43.575;P＜0.05),while the serum levels of dsDNA/NETs in the two groups at 5 d after surgery showed no significant changes compared with those at 24 h before surgery (P＞0.05).The ROC analysis showed that the area under the ROC curve (AUC) of the serum level of dsDNA/NETs at 24 h after surgery for predictingDVTwas0.837 (95％ confidence interval (CI)=0.763-0.911).When the dsDNA/NETs at 24 h after surgery was 0.46 mg/L,the sensitivity and specificity for diagnosing DVT were 87.1％ and 70.7％,respectively.The AUC of the serum level of dsDNA/NETs at 72 h after surgery for predicting DVT was 0.647 (95％CI=0.526-0.767).When the dsDNA/NETs at 72 h after surgery was 0.39 mg/L,the sensitivity and specificity for diagnosing DVT were 45.2％ and 86.6％,respectively.Conclusion The serum levels of NETs in patients with lower extremity DVT after total hip arthroplasty increase,so it may be involved in the development of lower extremity DVT.It may be a potential biomarker for predicting and screening out lower extremity DVT early after total hip arthroplasty.
NETL
NSTL
万方数据
维普
