ASSOCIATION BETWEEN FAM13A GENE POLYMORPHISM AND THE RISK OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE: A META-ANALYSIS
Objective To comprehensively evaluate the association of FAM13A gene polymorphism with chronic obstructive pulmonary disease (COPD) applying a meta-analysis.Methods.A computer search of case-control studies regarding correlation between FAM13A gene polymorphism and COPD in PubMed,CNKI,WanFang and EMbase database was conducted.The retrieval time range was from the day of building database to June 20,2016.In accordance with established standards,the literature was included,evaluated and data extracted by two reviewers.A Meta-analysis was done adopting RevMan 5.3 software.Results A total of seven studies involving 3 571 COPD cases and 4 344 healthy controls were included.The Meta-analysis demonstrated that COPD susceptibility was correlated with FAM13A rs7671167 polymorphism (CC+CT vs.TT:OR =0.76,95％CI=0.62-0.94,P ＜0.05).In the subgroup analysis by ethnicity,significant decreased risk of COPD was found in the Caucasian C allele carriers (CC+CT vs.TT:OR=0.63,95％CI=0.43-0.93,P＜0.05),but not in Asian (CC+CT vs.TT:OR=0.82,95％CI=0.64-1.05,P＞0.05).Conclusion FAM13A gene rs7671167 polymorphism is correlated with susceptibility of COPD in Caucasian,which may decrease the onset risk of COPD in Caucasian,but the correlation of risk of COPD with FAM13A gene rs7671167 polymorphism in Asian is still not sure.
family sequence similarity 13A genechronic obstructive pulmonary diseasepolymorphism, single nucleotidemeta-analysis
NETL
NSTL
万方数据
维普
