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高分级脑胶质瘤术后复发的相关影响因素分析

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目的 探讨影响高分级脑胶质瘤术后复发的相关因素,为临床对脑胶质瘤预后判断提供帮助.方法 回顾性分析我院神经外科150例高分级脑胶质瘤病人的临床资料,采用SPSS软件分析各因素与肿瘤复发的关系.结果 单因素分析结果显示,年龄(x2=21.74,P<0.05)、术前抽搐(x 2=9.76,P<0.05)、肿瘤病理分级(x 2=7.64,P<0.05)、术后放疗(x 2=21.79,P<0.05)、术后化疗(x 2=31.52,P<0.05)以及肿瘤分子标志物IDH1突变状态(x 2=33.79,P<0.05)与高分级脑胶质瘤病人术后复发有关;多元Logistic逐步回归分析结果显示,年龄(OR=4.29,95%CI=2.05~8.97,P<0.05)、术后放疗(OR=2.81,95%CI=1.24~6.37,P<0.05)、术后化疗(OR =7.69,95%%CI=3.04~19.44,P<0.05)、IDH1突变状态(OR=5.51,95%CI =2.64~11.49,P<0.05)是高分级脑胶质瘤病人术后复发的独立影响因素.结论 年龄>50岁、术后未行放化疗、IDH1野生型是高分级脑胶质瘤病人术后复发的危险因素.
INFLUENCING FACTORS FOR POSTOPERATIVE RECURRENCE OF HIGH-GRADE GLIOMA
Objective To investigate the influencing factors for postoperative recurrence of high-grade glioma,and to provide some help for prognostic evaluation of glioma.Methods A retrospective analysis was performed for the clinical data of 150 patients with high grade glioma who were treated in Department of Neurosurgery in our hospital.SPSS software was used to analyze the association between various factors and tumor recurrence.Results The univariate analysis showed that age (x2 =21.74,P<0.05),preoperative convulsion (x2 =9.76,P<0.05),tumor grade (x2 =7.64,P<0.05),postoperative radiotherapy (x2 =21.79,P<0.05),postoperative chemotherapy (x2 =31.52,P<0.05),and IDH1 mutation status (x2 =33.79,P<0.05)were associated with postoperative recurrence of high-grade glioma.The results of the multivariate logistic stepwise regression analysis showed that age (odds ratio (OR) =4.29,95 % confidence interval (CI) =2.05-8.97,P <0.05),postoperative radiotherapy (OR =2.81,95 % C I =1.24-6.3 7,P < 0.05),postoperative chemotherapy (OR =7.69,95 % C I =3.04-19.44,P < 0.05),and IDH 1 mutation status (OR =5.51,95 % CI =2.64-11.49,P <0.05) were independent influencing factors for postoperative recurrence in patients with high-grade glioma.Conclusion Age >50 years,absence of radiochemotherapy after surgery,and wildtype IDH1 are risk factors for postoperative recurrence in patients with high grade glioma.

gliomarecurrenceprognosisroot cause analysis

张亚、丁晓、于宁、陈红华、郭平、陆海军

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青岛大学附属医院肿瘤放疗科,山东青岛266003

烟台市莱阳中心医院肿瘤科

神经胶质瘤 复发 预后 影响因素分析

国家自然科学基金资助项目

81472812

2017

齐鲁医学杂志
青岛大学医学院

齐鲁医学杂志

影响因子:0.609
ISSN:1008-0341
年,卷(期):2017.32(4)
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