INFLUENCING FACTORS FOR POSTOPERATIVE RECURRENCE OF HIGH-GRADE GLIOMA
Objective To investigate the influencing factors for postoperative recurrence of high-grade glioma,and to provide some help for prognostic evaluation of glioma.Methods A retrospective analysis was performed for the clinical data of 150 patients with high grade glioma who were treated in Department of Neurosurgery in our hospital.SPSS software was used to analyze the association between various factors and tumor recurrence.Results The univariate analysis showed that age (x2 =21.74,P<0.05),preoperative convulsion (x2 =9.76,P<0.05),tumor grade (x2 =7.64,P<0.05),postoperative radiotherapy (x2 =21.79,P<0.05),postoperative chemotherapy (x2 =31.52,P<0.05),and IDH1 mutation status (x2 =33.79,P<0.05)were associated with postoperative recurrence of high-grade glioma.The results of the multivariate logistic stepwise regression analysis showed that age (odds ratio (OR) =4.29,95 % confidence interval (CI) =2.05-8.97,P <0.05),postoperative radiotherapy (OR =2.81,95 % C I =1.24-6.3 7,P < 0.05),postoperative chemotherapy (OR =7.69,95 % C I =3.04-19.44,P < 0.05),and IDH 1 mutation status (OR =5.51,95 % CI =2.64-11.49,P <0.05) were independent influencing factors for postoperative recurrence in patients with high-grade glioma.Conclusion Age >50 years,absence of radiochemotherapy after surgery,and wildtype IDH1 are risk factors for postoperative recurrence in patients with high grade glioma.