EXPRESSION AND CLINICAL SIGNIFICANCE OF Akt/mTOR SIGNALING PATHWAY IN CERVICAL SQUAMOUS CARCINOMA TISSUES
Objective To investigate the expression of the Akt/mTOR (protein kinase B/mammalian target of rapamycin) signaling pathway in cervical squamous carcinoma tissues and its clinical significance.Methods The expression of p-Akt and p-mTOR in 20 cases of normal cervical epithelium tissues (normal group),60 cases of cervical intraepithelial neoplasia (CIN) tissues (CIN group),and 60 cases of cervical carcinoma tissues (cervical carcinoma group) were determined by immunohistochemical SP method,and then their relationships with clinicopathological factors were analyzed.Results The positive rates of p-Akt expression in the normal group,CIN group,and cervical carcinoma group were 25.0％,46.67％,and 80.0％,respectively,and the cervical carcinoma group had a significantly higher positive rate of p-Akt expression than the CIN group and the normal group (x2=24.002,P＜0.01).There was a significant difference in the positive rate of p-mTOR expression between the normal group,the CIN group,and the cervical carcinoma group (20.0％,55.0％,and 88.3％;x2 =36.859,P＜0.05).The expression of p-Akt and p-mTOR was associated with the clinical stage of cervical carcinoma and lymph node metastasis (x2 =4.043-9.378,P＜0.05),but not with the degree of tumor differentiation and postoperative recurrence (P＞0.05).There was a positive correlation between the expression of p-Akt and p-mTOR in cervical squamous cell carcinoma (r=0.762,P＜0.01).Conclusion Positive expression of the Akt/mTOR signaling pathway in cervical squamous cell carcinoma tissues is associated with the tumor stage and lymph node metastasis,so it may serve as a new molecular marker for predicting the metastasis of cervical carcinoma and a therapeutic target.
uterine cervical neoplasmsAkt/mTOR signal transductionneoplasm metastasis
NETL
NSTL
万方数据
维普
