VALUE OF HIGH-RISK HUMAN PAPILLOMAVIRUS DETECTION IN THE TRIAGE OF PATIENTS WITH ATYPICAL SQUAMOUS CELLS OF UNDETERMINED SIGNIFICATION BASED ON CERVICAL FLUID CYTOLOGY TEST
Objective To investigate the value of high-risk human papillomavirus (HR HPV) detection in the triage of patients with atypical squamous cells of undetermined significance (ASCUS).Methods The thin-layer cytology test (TCT) was performed for 1 862 women,and HR-HPV detection and colposcopic biopsy were performed for those diagnosed with ASCUS.Results Of all women,196 were diagnosed with ASCUS,resulting in a positive rate of 10.5％.Of all the patients with ASCUS,31.1％ had HR-HPV,and the ≥35-year group had a significantly higher positive rate than the＜35-year group (73.3％ vs 12.5％,x 2 =71.9,P ＜ 0.01).HR-HPV infection was closely associated with high-level cervical intraepithelial neoplasia (x 2 =42.4,P ＜0.01) in both age groups (x2 4.8,P＜0.05;P =0.018).The ≥35-year group had significantly higher HRHPV infection rate and positive rate confirmed by pathologic diagnosis than the＜35-year group (x2 =65.52,39.01;P＜0.01).Conclusion Colposcopic biopsy should be performed for ASCUS patients with positive HR HPV for early identification and treatment of lesions.TCT should be performed regularly for ASCUS patients with negative HR-HPV.
human papillomavirusASCUShigh-level cervical intraepithelial neoplasiathin-cytologic test
NETL
NSTL
万方数据
维普
