首页|乳癌组织P53蛋白和Ki-67抗原表达及临床意义

乳癌组织P53蛋白和Ki-67抗原表达及临床意义

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目的 探讨人乳癌组织P53蛋白和Ki-67抗原的表达及其意义.方法 应用免疫组织化学方法,检测100例乳癌组织和50例癌旁正常乳腺组织中P53蛋白和Ki-67抗原的表达.结果 乳癌组织P53蛋白和Ki-67抗原的表达阳性率均显著高于正常组织(x 2=4.854、6.047,P＜0.05);P53蛋白和Ki-67抗原在TNMⅢ组的表达明显高于TNM Ⅰ～Ⅱ组(x 2=4.679、11.360,P＜0.05),腋窝淋巴结阳性组的表达明显高于腋窝淋巴结阴性组(x 2=11.081、6.109,P＜0.05);Ki-67抗原在术后复发组的表达明显高于术后未复发组(x 2=5.403,P＜0.05),P53蛋白的表达在术后复发与未复发组比较差异无显著性(P＞0.05);Ki-67抗原在组织学分级3级组的表达阳性率明显高于组织学分级1～2级组,差异有显著性(x2=7.760,P＜0.05);不同组织学分级乳癌组织中P53蛋白表达阳性率比较差异无显著性(P＞0.05).乳癌组织P53蛋白和Ki-67抗原的表达有显著正相关性(r=0.286,P＜0.05).P53蛋白和Ki-67抗原表达阴性的病人5年生存率优于表达阳性者,差异有显著性(x 2=6.862、7.963,P＜0.05).结论 P53蛋白和Ki-67抗原在乳癌组织中高表达提示预后不良.
EXPRESSION OF P53 AND Ki-67 IN BREAST CANCER TISSUES AND ITS CLINICAL SIGNIFICANCE
Objective To investigate the expression of P53 and Ki 67 in human breast cancer tissues and its clinical significance.Methods The expression of P53 and Ki-67 in the breast cancer tissues (n =100) and the normal tissues adjacent to breast cancer (n=50) of 100 patients with breast cancer was measured by immunohistochemistry.Results The expression of P53 and Ki-67 in the breast cancer tissues was significantly higher than that in the normal tissues (x 2=4.854,6.047;P ＜ 0.05).The expression of P53 and Ki-67 in the breast cancer tissues in TNM Ⅲ stage was significantly higher than that in the breast cancer tissues in TNM Ⅰ Ⅱ stage (x2=4.679,11.360;P＜0.05).The expression of P53 and Ki 67 in the involved axillary lymph nodes was significantly higher than that in the normal axillary lymph nodes (x2 =11.081,6.109;P ＜0.05).There was no significant difference in the expression of P53 between the tissues with and without postoperative recurrence (P＞0.05).The expression of Ki67 in the tissues with postoperative recurrence was significantly higher than that in the tissues without postoperative recurrence (x2 =5.403,P＜0.05).There was no significant difference in the expression of P53 between the breast cancer tissues of different histological grades (P＞0.05),but the expression of Ki-67 in the breast cancer tissues of histological grade 3 was significantly higher than that in the breast cancer tissues of histological grade 1-2 (x 2 =7.760,P ＜0.05).There was a significant positive correlation between the expression of P53 and Ki-67 in the breast cancer tissues (r=0.286,P＜0.05).The 5 year survival rate of patients without the expression of P53 and Ki-67 was significantly higher than that of patients with the expression of P53 and Ki-67 (x2 =6.862,7.963;P＜0.05).Conclusion The high expression of P53 and Ki-67 in the breast cancer tissues suggests poor prognosis of breast cancer.

breast neoplasmstumor suppressor protein 53Ki-67 antigenimmunohistochemistry

侯红、方堃、陈耀坤、王炳高、李振凤

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青岛大学第二附属医院乳腺科,山东青岛266042

乳房肿瘤 肿瘤抑制蛋白质P53 Ki-67抗原 免疫组织化学

2017

10.13362/j.qlyx.201704009

齐鲁医学杂志
青岛大学医学院

齐鲁医学杂志

影响因子：0.609
ISSN：1008-0341
年,卷(期)：2017.32(4)
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