CLINICAL EFFECT OF LAMIVUDINE COMBINED WITH TENOFOVIR DISOPROXIL FUMARATE AND EFAVIRENZ IN TREATMENT OF AIDS
Objective To investigate the clinical effect and adverse effects of lamivudine (3TC) combined with tenofovir disoproxil fumarate (TDF) and efavirenz (EFV) in the treatment of AIDS.Methods A total of 60 AIDS patients who were admitted to our hospital from 2014 to 2016 were enrolled and treated with 3TC combined with TDF and EFV.The changes in CD4 cells and AIDS viral load after treatment were compared between the patients with different CD4 levels or different ages.Results All groups had a significant increase in the CD4 level after treatment;the patients with CD4 cells (200-350)× 106/L before treatment had a significantly greater increase in CD4 cells than those with ＜200 × 106/L before treatment,and the low-age group had a significantly greater increase in CD4 cells than the high-age group (t=2.238-2.478,P＜0.05).All groups had a significant reduction in AIDS viral load after treatment,and there was no significant difference between the patients with different CD4 levels or different ages.There were few adverse reactions which were well tolerable in these patients.Conclusion In AIDS patients,3TC combined with TDF and EFV has a good overall clinical effect,few adverse effects,and good tolerability.
NETL
NSTL
万方数据
维普
