EFFECT OF LOW-DOSE INTERFERON-α COMBINED WITH VITAMIN A IN TREATMENT OF MEASLES IN CHILDREN
Objective To investigate the effect of low-dose interferon-α combined with vitamin A in the treatment of measles in children.Methods A total of 90 children with measles were equally and randomly divided into observation group and control group.The control group was orally given vitamin A oil pills in addition to the conventional treatment,while the observation group was given the intramuscular or subcutaneous injection of recombinant human interferon-α-2b (IFN-α-2b) in addition to the treatment for the control group.The T lymphocyte subsets (CD3+,CD4+,CD4+/CD8+) in the two groups were determined before and after treatment.The following indices were observed and compared between the two groups:length of hospital stay,fever clearance time,time to cough resolution,time to diarrhea resolution,and incidence of complications.Results The observation group had significantly shorter length of hospital stay,fever clearance time,time to cough resolution,and time to diarrhea resolution than the control group (t =3.422-4.849,P＜0.05),and had a significantly lower incidence of complications (such as pneumonia and laryngitis) than the control group (x2 =11.520,P ＜0.05).After treatment,the observation group had significantly increased percentages of CD3+ and CD4+ T lymphocytes and CD4+/CD8+ ratio and a significantly reduced percentage of CD8+ T lymphocytes (t=2.606-7.221,P＜0.05).And after treatment,the observation group had significantly increased percentages of CD3+ and CD4+ T lymphocytes and CD4+/CD8+ ratio and a significantly reduced percentage of CD8+ T lymphocytes compared with the control group (t=2.212-4.742,P＜0.05).Conclusion Low-dose IFN-α-2b combined with vitamin A can significantly improve the clinical symptoms of children with measles and rapidly restore the inhibited T lymphocyte function,so it holds promise for clinical application.
NETL
NSTL
万方数据
维普
