BCL-2-ASSOCIATED ATHANOGENE 3 EXPRESSION IN CERVICAL CANCER AND ITS CLINICAL SIGNIFICANCE
Objective To examine the expression of Bcl-2-associated athanogene 3 (BAG3) in cervical cancer and its clinical significance.Methods The BAG3 gene and BAG3 protein expression in 103 cervical cancer tissues,50 cervical intraepithelial neoplasia (CIN) tissues,and 40 normal cervical tissues were measured by immunohistochemistry and quantitative real-time PCR.The effect of BAG3 protein expression on the survival of cervical cancer patients was analyzed by the Kaplan-Meier survival curve and log-rank test.Results The BAG3 protein expression rate was significantly higher in the cervical cancer group than in the CIN and control groups (x2 =27.167 and 28.514,both P＜0.01).Similarly,the relative BAG3 mRNA expression was significantly higher in in the cervical cancer group than in the CIN and control groups (t =30.453 and 26.295,both P＜0.01).BAG3 protein and mRNA expression in cervical cancer tissues was correlated with FIGO staging,differentiation,lymph node metastasis,and myometrial invasion (x2=4.691-7.530,P＜0.05;t =28.825-35.696,P＜0.01).Kaplan-Meier survival analysis showed that the mean survival time was significantly shorter in the BAG3 protein-positive group than in the BAG3 protein-negative group (37.96 months vs 53.70 months,x2=4.555,P＜0.05).Conclusion BAG3 is highly expressed in cervical cancer tissues.It may be involved in the development,progression,invasion,and metastasis of cervical cancer,and is closely associated with patient progno sis.Therefore,BAG3 is a potential biomarker for cervical cancer diagnosis and prognosis.
NETL
NSTL
万方数据
维普
