DIAGNOSTIC VALUE OF SCC-AG, CATH-D, AND CA125 FOR CERVICAL SQUAMOUS CELL CARCINOMA AND ITS METASTASIS
Objective To evaluate the value of combined measurement of squamous cell carcinoma antigen (SCC-Ag),cathepsin D (Cath-D),and carbohydrate antigen (CA125) in the diagnosis of cervical squamous cell carcinoma and its metastasis.Methods Fifty-one patients with firstly diagnosed cervical squamous cell carcinoma (cervical cancer group),as well as 30 patients with cervical intraepithelial neoplasia (CIN group) and 30 healthy controls in the same age and in the same period,were enrolled for this study.The levels of SCC-Ag,Cath-D,and CA125 were determined and compared between the three groups.Based on pathological diagnosis and/or imaging staging,the receiver operating characteristic (ROC) curve was used to evaluate the efficacy of SCC-Ag,Cath-D,and CA125 alone and in combination for the diagnosis of cervical cancer and its metastasis.Results The levels of SCC-Ag,Cath-D,and CA125 were significantly higher in the cervical cancer group than in the control group or CIN group (F=17.693-51.815,P＜0.05).The subgroup analysis showed that the levels of SCC-Ag,Cath-D,and CA125 in the metastatic group were significantly higher than those in non-metastatic group (t =2.043-2.095,P ＜0.05).The diagnostic efficiency of combined measurement of SCC-Ag,Cath-D,and CA125 was significantly higher than that of SCC-Ag,Cath-D,or CA125 alone in the diagnosis for cervical cancer (area under the ROC curve (AUC)=0.94,0.78,0.87 and 0.82,respectively),and the optimal cut-off point for combined measurement was SCC-Ag ＞1.49μg/L,Cath-D ＞10.83 ng/L,and CA125 ＞18.95 kU/L.The diagnostic efficiency of combined measurement of SCC-Ag,Cath-D,and CA125 was significantly higher than that of SCC-Ag,Cath-D,or CA125 alone in the diagnosis of the metastasis of cervical cancer (AUC=0.91,0.70,0.83 and 0.80,respectively),and the optimal cut-off point was SCC-Ag ＞1.96 μg/L,Cath-D ＞13.53 ng/L,and CA125 ＞22.42 kU/L.Conclusion A combination of SCC-Ag,Cath-D,and CA125 has a high value in the diagnosis of cervical squamous cell carcinoma and the prediction of tumor metastasis.
NETL
NSTL
万方数据
维普
