VALUE OF PREOPERATIVE FIB AND PLT IN ASSESSING THE PROGNOSIS OF PATIENTS WITH UPPER URINARY TRACT UROTHELIAL CARCINOMA
Objective To investigate the value of preoperative fibrinogen (FIB) and platelet (PLT) count in assessing the prognosis of patients with upper urinary tract urothelial carcinoma (UUTUC).Methods We retrospectively analyzed the clinical data of 140 patients with non-metastatic UUTUC who underwent surgical treatment in our hospital from January 2005 to December 2011.Clinicopathological features were compared between patients with different preoperative FIB levels and PLTs.Survival analysis was performed using Kaplan-Meier method and log-rank test,and risk factor analysis was performed using the Cox proportional hazards regression model.Results There was only a significant difference in pathological staging between low-FIB group (＜4.0 g/L) and high FIB group (≥4.0 g/L) (x2 =7.241,P＜0.01).However,there was no significant difference in each clinicopathological feature between high-PLT group and Iow-PLT group (P ＞0.05).There were significant differences in cancerspecific survival rate and recurrence-free survival rate between low-FIB group and high-FIB group (x2 =8.19,7.162;P ＜ 0.05).Pathological staging and preoperative FIB were independent risk factors for cancer-specific survival (HR =13.097 and 0.429,both P＜0.05).Conclusion Preoperative FIB is an independent risk factor for cancer-specific survival in patients with UUTUC.Patients with high preoperative FIB levels (≥4.0 g/L) have poor prognosis.Preoperative PLT has no significant effect on the prognosis of patients with UUTUC.
NETL
NSTL
万方数据
维普
