IMPACT OF PROBIOTICS COMBINED WITH EARLY ENTERAL NUTRITION ON BIOCHEMICAL AND NUTRITIONAL PARAMETERS IN PATIENTS WITH SEVERE CRANIOCEREBRAL INJURY
Objective To investigate the impact of probiotics combined with early enteral nutrition on biochemical and nutritional parameters in patients with severe craniocerebral injury.Methods A total of 165 patients with severe craniocerebral injury were randomly divided into four groups:routine nasogastric feeding group (group A;n =42),nasogastric feeding with probiotics group (group B;n =39),nasointestinal tube feeding group (group C;n =43) and nasointestinal tube feeding with probiotics group (group D;n=41).With the same intake of calories and nitrogen,the nutritional parameters such as serum albumin (ALB) and hemoglobin (Hb) were determined on the 1st,7th,and 14th days.Meanwhile,the changes in gastrointestinal function and complication incidence in each group were monitored and compared.Results On the 14th day of treatment,group B had a significantly greater improvement in ALB than group A (t =3.32,P ＜0.05);group D had a significantly greater improvement than group C (t =2.75,P＜0.05).Similarly,group B had a significantly higher increase in Hb than group A (t =3.25,P＜0.05);group D had a significantly higher increase than group C (t =2.99,P ＜0.05).Group B had a significantly more improvement in Glasgow Coma Scale score than group A (t=3.40,P＜0.05);group D had a significantly more improvement than group C (t =2.51,P＜0.05).Moreover,group B had significantly lower leukocyte count (t =3.21,P＜0.05),C reactive protein (t =3.01,P＜0.05),and procalcitonin (t =2.31,P＜0.05) than group A;group D had significantly lower leukocyte count (t =3.42,P＜0.05),C-reactive protein (t =3.65,P＜0.05),and procalcitonin (t =2.46,P＜0.05) than group C.Additionally,group B had significantly lower incidence rates of gastrointestinal symptoms such as abdominal distension,diarrhea,and reflux than group A (x2 =3.98,P＜0.05);group D had significantly lower incidence rates than group C (x2 =4.11,P＜0.05).Conclusion Probiotics combined with enteral nutrition can effectively protect the gastrointestinal mucosa of patients with severe craniocerebral injury and reduce gastrointestinal complications.
NETL
NSTL
万方数据
维普
