摘要
目的 描述和分析1973-2019年内蒙古地区结直肠癌死亡情况,为结直肠癌的防控提供科学依据.方法 对1973-2005年3次全国死因回顾调查和2011-2019年敖汉旗、开鲁县、临河区、牙克石市的结直肠癌死亡数据进行整理,计算其粗死亡率、中国人口标化死亡率(ASRC)、世界人口标化死亡率(ASRW)、0～74岁累积死亡率等指标,根据1982年全国人口普查标准人口年龄构成和Segi's世界标准人口构成计算人口年龄标化率.采用Joinpoint趋势分析软件计算年度变化百分比(APC)及平均年度变化百分比(AAPC)并分析内蒙古自治区1973-2019年结直肠癌死亡的时间变化趋势.结果 1973-1975、1990-1992、2003-2005、2011和2019年男性结直肠癌ASRW分别为3.37/10万、6.76/10 万、7.71/10 万、6.38/10 万和 10.20/10 万,女性分别为 2.65/10 万、3.12/10 万、5.27/10 万、5.48/10 万和5.37/10万,男性均高于女性.Joinpoint分析结果显示,1973-2019年内蒙古地区结直肠癌ASRC(APC=1.93％,P＜0.001)和ASRW(APC=2.09％,P＜0.001)总体呈上升趋势.男性和女性结直肠癌死亡率均有逐渐升高的趋势,且男性标化死亡率增速高于女性.结直肠癌粗死亡率从1973-1975年的2.10/10万上升到2019年的12.96/10万,APC为4.35％,男性结直肠癌粗死亡率APC为4.33％,女性为4.49％,均P＜0.001.60～岁年龄组全性别(AAPC=1.74％,P=0.019)和男性(AAPC=2.01％,P=0.015)结直肠癌死亡率随时间变化有明显增长趋势,女性死亡率随时间变化增长但趋势不明显(AAPC=1.81％,P=0.091);65～84岁各年龄组结直肠癌死亡率均呈明显上升趋势.结论 1973-2019年内蒙古地区结直肠癌死亡率呈明显上升趋势,变化趋势存在年龄及性别差异,应重视早筛早治和健康教育工作.
Abstract
Objective To describe and analyze the mortality of colorectal cancer in Inner Mongolia Autonomous Region from 1973 to 2019,and to provide useful date for the prevention and control of colorectal cancer.Methods The three nation-wide retrospective cause-of-death data from 1973 to 2005 were investigated and the mortality data of colorectal cancer were selected from cancer registration areas of Aohan Qi,Kailu,Linhe and Yakeshi from 2011 to 2019.The mortality rate,the age-standardized mortality rates by Chinese standard population(ASRC)and by world standard population(ASRW),0-74 years old cumulative mortality rate were calculated,the age-standardized rate was calculated with the Chinese popula-tion in 1982 and the world Segi's standard population.The annual percentage change(APC)and average annual percent-age change(AAPC)were calculated with Joinpoint software,and the temporal trend of colorectal cancer mortality was an-alyzed in Inner Mongolia Autonomous Region from 1973 to 2019.Results The results showed that the ASRW of male colorectal cancer in 1973-1975,1990-1992,2003-2005,2011,and 2019 were 3.37/100 000,6.76/100 000,7.71/100 000,6.38/100 000,and 10.20/100 000,respectively.The ASRW of female colorectal cancer was 2.65/100 000,3.12/100 000,5.27/100 000,5.48/100 000,and 5.37/100 000,respectively,with males being higher than females.The Join-point analysis results showed that from 1973 to 2019,ASRC(APC=1.93％,P＜0.001)and ASRW(APC=2.09％,P＜0.001)of colorectal cancer in Inner Mongolia showed an overall upward trend.The mortality rate of colorectal cancer in both males and females is gradually increasing,with age standardized mortality rates were increasing faster for males than females.The crude mortality rate of colorectal cancer increased from 2.10/100 000 in 1973-1975 to 12.96/100 000 in 2019,with an APC of 4.35％.The crude mortality rate of colorectal cancer in males and females was 4.33％and 4.49％,both P＜0.001.The mortality rate of colorectal cancer in the 60-year-old age group showed a significant increase over time for both genders(AAPC=1.74％,P=0.019)and males(AAPC=2.01％,P=0.015),while the mortality rate in fe-males increased over time but the trend was not significant(AAPC=1.81％,P=0.091);The mortality rate of colorectal cancer in all groups aged 65 to 84 showed a significant upward trend.Conclusion The mortality rate of colorectal cancer in Inner Mongolia from 1973 to 2019 showed a significant upward trend,with age and gender differences in the trend.Ear-ly screening,treatment,and health education should be emphasized.
NETL
NSTL
维普
万方数据