Efficacy evaluation of neoadjuvant chemotherapy in breast cancer
Objective To provide a detailed overview of the assessment of neoadjuvant chemotherapy(NAC)efficacy in breast cancer and propose future directions by comparing existing standardized evaluation procedures to accurately evaluate NAC efficacy.Methods A comprehensive literature search was conducted in the PubMed and CNKI databases by using Chinese and English keywords such as"breast cancer,neoadjuvant therapy,neoadjuvant chemotherapy,pathological com-plete response,efficacy assessment"from Jan 1995 to June 2023.Inclusion criteria:(1)Studies on imaging in the clinical assessment of NAC for breast cancer;(2)Methods and merits or weakness of NAC pathological assessment;(3)Proce-dures for evaluating neoadjuvant therapy(NAT)efficacy.Exclusion criteria:Articles with the specified keywords but lac-king relevance were excluded.A total of 56 articles were ultimately included,comprising 48 in English and 8 in Chinese,based on the established criteria.Results Research indicates that precise preoperative clinical assessment following NAC in breast cancer allows the prediction of tumor pathological response,offering crucial information for subsequent treat-ments.The postoperative pathology results of the primary tumor and lymph nodes after NAC are considered the gold standard for evaluation.These outcomes are closely associated with patient prognosis,providing essential guidance for for-mulating personalized postoperative comprehensive treatment plans.Conclusion Accurate assessment of NAC efficacy in breast cancer is crucial for selecting subsequent personalized treatment plans and predicting patient prognosis.Currently,multiple evaluation procedures are available,but lack uniformity and standards.Therefore,the establishment of unified as-sessment metrics and standards may enhance the precision and reliability of evaluation methods for NAC efficacy.This could further improve the accuracy of assessing NAC efficacy,providing better support for treatment decisions and prog-nosis evaluation in breast cancer patients.
breast cancerneoadjuvant therapyneoadjuvant chemotherapypathological complete responseefficacy evalua-tion
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