摘要
目的 探究雷帕霉素靶蛋白(mTOR)在肝癌发生、进展及治疗中的作用机制以及应用局限与优势.方法 应用Pubmed数据库,以"mtor、liver cancer、inhibitor"为英文关键词,检索2001-2023年相关文献.纳入标准:(1)mTOR的定义、分型及作用;(2)mTOR与肝癌相关的动物及临床实验研究;(3)mTOR抑制剂研究进展.排除标准:(1)会议摘要;(2)低质量文献.最终纳入70篇相关文献.结果 mTOR影响肝癌发生进展作用机制主要包括促进肝癌细胞增殖与转移、抑制肝癌细胞凋亡与自噬、破坏肿瘤微环境及产生药物耐药性.mTOR抑制剂治疗肝癌是一把双刃剑,在延长患者生存期、减少肝癌复发、抗耐药性的同时,也会损害肝功能,甚至无益.结论 mTOR信号通路对肝癌的发生、进展及治疗具有重要临床意义,mTOR抑制剂虽然在肝癌的治疗中具有显著的优势,但也存在不足之处.
Abstract
Objective To investigate the mechanism of action of the mechanistic target of rapamycin(mTOR)in the devel-opment,progression and treatment of hepatocellular carcinoma.Methods The Pubmed database was used to search the relevant literature from 2001 to 2023 using"mTOR,liver cancer,inhibitor"as keywords.Inclusion criteria:(1)defini-tion,typing and role of mTOR;(2)animal and clinical studies on mTOR in liver cancer;(3)research progress on mTOR inhibitor.Exclusion criteria:(1)conference abstracts;(2)low-quality literature.Seventy relevant literature were finally included.Results The mechanism of mTOR affecting the progression of hepatocellular carcinoma mainly includes promo-ting the proliferation and metastasis of hepatocellular carcinoma cells,inhibiting apoptosis and autophagy of hepatocellular carcinoma cells,destroying the microenvironment of tumors,and generating drug resistance.mTOR inhibitor treatment of hepatocellular carcinoma is a double-edged sword,which can prolong the patients'survival period,reduce the recur-rence of hepatocellular carcinoma,and resist the resistance of drug,but it can also damage the liver function,and even not be beneficial.Conclusions The mTOR signaling pathway is clinically important for the occurrence,progression and treat-ment of hepatocellular carcinoma.mTOR inhibitors,although having significant advantages in the treatment of hepatocel-lular carcinoma,also have shortcomings.
基金项目
国家自然科学基金面上项目(81973733)
深圳市科技计划(JCYJ20220530172812028)
深圳市龙岗医疗卫生科技创新计划(LGK-CYLWS2021000015)
深圳市龙岗区医疗卫生技术攻关项目(LGK-CYLWS2022006)
NETL
NSTL
万方数据