Disease burden and trends of early-onset esophageal cancer from 1990 to 2019:a comparative analysis between China and global burden
Objective To describe and investigate the temporal trend of early-onset esophageal cancer burden in China from 1990 to 2019,and compare it with the global burden.Methods The 2019 Global Burden of Disease(GBD 2019)study da-ta were used to analyze the incidence,mortality,prevalence and disability adjusted life years(DALY)rate of early-onset esophageal cancer(20-49 years)in China from 1990 to 2019 based on age structure of GBD world standard population,and age-standardized rates were calculated by year and sex and were compared with the global rates.Age-standardized mortality and incidence were used for calculation[1-mortality-to-incidence ratio(MIR)],which was a proxy of 5-year relative survival rate.The proportions of new cases and deaths of early-onset esophageal cancer from 1990 to 2019 to those in total were calculated and stratified by year and sex.The Joinpoint regression model was used to calculate average annual percentage change(AAPC)of the four indexes mentioned above from 1990 to 2019.Results From 1990 to 2019,the age-standardized incidence,mortality,prevalence and DALY rates of early-onset esophageal cancer in China were higher than the global overall level.In 2019,the age-standardized incidence,mortality,prevalence and DALY rates of early-onset e-sophageal cancer in China were 1.96 per 100 000,1.46 per 100 000,5.31 per 100 000 and 66.95 per 100 000,respective-ly,the corresponding global indexes were 1.19 per 100 000,0.96 per 100 000,2.81 per 100 000 and 44.23 per 100 000,respectively.In 2019,the standardized rates of early onset esophageal cancer in males in China and globally were higher than those counterparts in females.Except for the standardized mortality rate and standardized DALY rate of early onset esophageal cancer in Chinese women were lower than the global level(0.31 per 100 000 vs 0.47 per 100 000 and 14.80 per 100 000 vs 22.34 per 100 000,respectively),the standardized rates of early onset esophageal cancer in both males and fe-males in China were higher than global levels.[1-MIR]of early-onset esophageal cancer in China increased from 0.10 to 0.26,and the global[1-MIR]increased from 0.12 to 0.19.From 1990 to 2019,the proportions of early onset esopha-geal cancer in China were lower than the global levels.In 2019,the proportions of new cases and deaths in China were 5.59％and 4.50％,respectively,and the corresponding global levels were 7.64％and 6.62％.From 1990 to 2019,the age-standardized incidence,mortality,prevalence and DALY rates of early-onset esophageal cancer in China showed a sta-tistically significant decline trend,the magnitude of trend was greater than the global with APCC being-2.03％,-2.77％,-0.88％and-2.74％,respectively,and the corresponding global indexes were-1.31％,-1.63％,-0.68％and-1.61％,respectively.Conclusions The disease burden of early-onset esophageal cancer in China showed a decline trend but was still higher than the global overall level.More attention should be paid for the comprehensive pre-vention and control of early-onset esophageal cancer.
NETL
NSTL
万方数据
