Comparison of 68Ga-FAPI and 18F-FDG PET/CT imaging in the detection of esophageal cancer lesions
Objective To evaluate the ability of 68Ga-FAPI PET/CT in detecting primary and metastatic lesions in patients with initially diagnosed esophageal cancer and compare it with 18F-FDG PET/CT.Methods A total of 32 patients with e-sophageal cancer who underwent 18F-FDG PET/CT and 68Ga-FAPI PET/CT within one week in the First Affiliated Hos-pital of Xiamen University from December 2019 to December 2022 were retrospectively analyzed,including 26 males and 6 females,aged between 43 and 85 years,with an average age of(62.16±10.11)years.Paired t-test or Wilcoxon rank test was used to compare SUVmax and the number of lesions detected by 68Ga-FAPI and 18F-FDG.Pearson correlation analysis was used to determine the relationship between radioactive tracers uptake and the size of the primary lesions.Analysis of variance or Kruskal-Wallis rank sum test was used to compare the difference of SUVmax among the three different patho-logical types of cancer.Results In 32 patients with initially diagnosed esophageal cancer,30 cases of squamous cell carci-noma and 2 cases of adenocarcinoma were confirmed by pathological results.SUVmax of 68Ga-FAPI was higher than that of 18F-FDG in primary oesophageal cancer(17.43±5.74 vs 12.94±4.67,t=-4.128,P＜0.001).The longitudinal diame-ter of the primary lesion was not correlated with SUVmax of 68Ga-FAPI(r=0.111,P=0.545),but was significantly correlated with SUVmax of 18F-FDG(r=0.368,P=0.038).In 130 suspected lymph node metastases detected by both methods,SUVmax of 68Ga-FAPI was higher than that of 18F-FDG PET/CT[8.72(5.30,12.68)vs 5.88(3.78,13.50),Z=-6.150,P＜0.001],and 68Ga-FAPI PET/CT detected more lymph node metastases in the same patient[3.0(1.0,5.0)vs 3.0(2.0,5.0),Z=-2.254,P=0.024].In 21 distant metastases detected by both methods,68 Ga-FAPI PET/CT had higher SUVmax than 18F-FDG(12.11±4.42 vs 6.37±1.73,t=-6.263,P＜0.001).Conclusions 68 Ga-FAPI has higher uptake than 18 F-FDG PET/CT in primary and metastatic lesions of esophageal cancer and can observe more metastatic lesions in visual analysis,which is beneficial to the individualized treatment of patients with initially diagnosed esophageal cancer.
NETL
NSTL
万方数据
