首页|Al18F-NOTA-FAPI-04 PET/CT 在乳腺癌中的初步应用研究

Al18F-NOTA-FAPI-04 PET/CT 在乳腺癌中的初步应用研究

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目的 探讨Al18F-NOTA-FAPI-04 PET/CT显像在乳腺癌诊断中的应用价值,并分析乳腺癌原发病灶Al18F-NO-TA-FAPI-04摄取与其病理特征的关系.方法 回顾分析2022-06-17-2022-11-09在中国医学科学院北京协和医学院北京协和医院行Al18F-NOTA-FAPI-04 PET/CT检查的29例初诊怀疑乳腺癌患者的临床资料.所有患者均经手术切除或穿刺活检确诊乳腺癌.在PET/CT图像上勾画各脏器及乳腺癌病灶的感兴趣区(ROI),获取各脏器及乳腺癌病灶的最大标准摄取值(SUVmax)和平均标准摄取值(SUVmean).比较不同病理特征乳腺癌PET/CT指标差异,符合正态分布的数据以X±S表示,2组间比较采用两独立样本t检验;不符合正态分布的数据用M(P25,P75)表示,2组间比较采用Mann-Whitney U检验,多组间比较采用Kruskal-Wallis H检验.结果 体内显像示Al18 F-NOTA-FAPI-04经泌尿系统和肝胆系统排泄,其生理性摄取主要在涎腺、甲状腺、胰腺、肾皮质、子宫和肌肉.共发现31个乳腺癌原发病灶和28个淋巴结转移病灶,原发病灶SUVmax和SUVmean分别为13.54±5.92和8.34±3.74,淋巴结转移病灶分别为8.94(4.86,15.42)和5.37(3.03,9.56).不同病理特征乳腺癌原发病灶SUVmax和SUVmean差异无统计学意义,均P＞0.05.结论 Al18F-NOTA-FAPI-04高度浓聚于乳腺癌病灶,PET/CT图像对比度高,在乳腺癌的诊断中具有较好的临床应用价值.Al18F-NOTA-FAPI-04摄取与乳腺癌病理特征无关.
The preliminary study of Al18F-NOTA-FAPI-04 PET/CT in breast cancer
Objective To investigate the value of Al18 F-NOTA-FAPI-04 PET/CT imaging for clinical application in breast cancer,and to explore the correlation between the uptake of Al18F-NOTA-FAPI-04 in primary breast cancer and its path-ological features.Methods From June 2022 to November 2022,29 patients who underwent Al18F-NOTA-FAPI-04 PET/CT with a primary diagnosis of suspected breast cancer were retrospectively analyzed.All patients were diagnosed with breast cancer by surgical resection or biopsy.The ROI of each organ and breast cancer lesion was outlined on PET/CT images,and the SUVmax and SUVmean were obtained.The indices of different pathological factors of breast cancer were compared by the independent sample t test,Mann-Whitney U test,and Kruskal Wallis H test.Results In vivo imaging showed that Al18F-NOTA-FAPI-04 was excreted through urinary system and hepatobiliary system,and its physiological uptake was mainly in salivary gland,thyroid,pancreas,renal cortex,uterus and muscle.A total of 31 breast cancer pri-mary lesions and 28 lymph node metastases were found.The SUVmax and SUVmean of primary lesions were 13.54±5.92 and 8.34±3.74,respectively.The SUVmax and SUVmean of lymph node metastases were 8.94(4.86,15.42)and 5.37(3.03,9.56),respectively.There was no significant difference in SUVmax and SUVmean of breast cancer primary lesions with different pathological features,all P＞0.05.Conclusions Al18 F-NOTA-FAPI-04 is highly concentrated in breast cancer lesions.Al18 F-NOTA-FAPI-04 PET/CT imaging has high contrast and is clinically useful in the diagnosis of breast cancer.Al18 F-NOTA-FAPI-04 uptake is not associated with pathological features of breast cancer.

breast cancerfibroblast activating protein inhibitorpositron emission tomographystandardized uptake valuepathological features

郝志鑫、潘博、任超、周易冬、孙强、霍力

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中国医学科学院北京协和医学院北京协和医院核医学科,疑难重症及罕见病国家重点实验室,中国医学科学院罕见病研究中心,核医学分子靶向诊疗北京市重点实验室,北京 100730

中国医学科学院北京协和医学院北京协和医院乳腺外科,疑难重症及罕见病国家重点实验室,中国医学科学院罕见病研究中心,核医学分子靶向诊疗北京市重点实验室,北京 100730

乳腺癌 成纤维细胞激活蛋白抑制剂 正电子发射断层扫描 最大标准摄取值 病理特征

国家自然科学基金中国医科院医学与健康科技创新工程项目中国医科院医学与健康科技创新工程项目中国医科院医学与健康科技创新工程项目中国医科院医学与健康科技创新工程项目北京协和医院中央高水平医院临床科研专项北京协和医院中央高水平医院临床科研专项

82071967CIFMS-2021-I2M-1-002CIFMS-2021-I2M-1-003CIFMS-2021-I2M-1-014CIFMS-2021-I2M-1-0252022-PUMCH-A-1652022-PUMCH-B-039

2024

10.16073/j.cnki.cjcpt.2024.05.03

中华肿瘤防治杂志
中华预防医学会 山东省肿瘤防治研究院

中华肿瘤防治杂志

CSTPCD北大核心
影响因子：1.292
ISSN：1673-5269
年,卷(期)：2024.31(5)
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