Objective To explore the uptake ability of 68Ga-FAPI-04 by different liver tumors,and analyze the potential dif-ferential diagnostic value of 68Ga-FAPI-04 PET/CT in liver tumors.Methods We analyzed the imaging data of 70 patients with suspected liver cancer in Affiliated Hospital of Southwest Medical University,retrospectively.All patients under-went 68Ga-FAPI-04 PET/CT examination.We divided these patients into two groups according to the pathological results and imaging examination results,including 45 primary liver tumor(25 hepatocellular carcinoma,16 cholangiocarcinoma,4 hemangioma)and 25 liver metastases.The difference in SUVmax between primary liver cancer and liver metastasis was analyzed by independent sample t-test.The differences in SUVmax between hepatocellular carcinoma,cholangiocarcinoma,and liver metastasis were analyzed.The relationships between the length and diameter of intrahepatic lesions and SUVmax were analyzed by Pearson's test.The diagnostic ability of each indicator were analyzed by receiver operating characteristic curve(ROC)analysis.Results The difference was statistically significant between primary liver cancer(hepatocellular carcinoma and cholangiocarcinoma)and liver metastases in the uptake ability of imaging agents(P＜0.05).There was no statistically significant difference in the uptake ability of imaging agents between hepatocellular carcinoma and cholangio-carcinoma.The cholangiocarcinoma group's liver lesion tracer uptake was the highest,the mean SUVmax was 14.90± 5.33.The mean SUVmax for hepatocellular carcinoma group's lesion was 9.98±4.92.The mean SUVmax for hepatocellular carcinoma group's lesion was 6.57±2.82.Among the 66 patients with primary liver cancer and liver metastases who underwent 68 Ga-FAPI-04 PET/CT,when the Youden index was 0.476,the SUVmax boundary value was 7.600.At this time,the corresponding sensitivity of 68Ga-FAPI-04 PET/CT was 0.756,the specificity was 0.720.There was no rela-tionship between the long diameter of primary liver cancer focus and the SUVmax(r=0.200,P=0.211).There was a sig-nificant correlation between the long diameter of liver metastases and the SUVmax(r=0.570,P=0.003).Conclusion As a new tracter,68Ga-FAPI-04 has great potential in the diagnosis of liver diseases,and it has potential value in distinguis-hing primary liver cancer,liver metastasis and benign lesions.
fibroblast activation protein inhibitionlivergalliumpositron emission tomographycomputed tomographytumour
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