Head-to-head comparison of 18F-FAPI and 18 F-FDG PET/CT in diagnosing peritoneal carcinoma
Objective To evaluate and compare the diagnostic efficacy of 18F-FAPI PET/CT and 18F-FDG PET/CT exami-nations in detecting peritoneal carcinomatosis(PC).Methods Totally 42 PC patients were enrolled based on histopatho-logical findings,typical radiological appearances,and clinical imaging follow-up,including 13 males and 29 females.The median age was 61 years(53.75-68.00 years).Tumor type:12 gastric cancer,10 ovarian cancer,9 colorectal cancer,5 liver cancer,2 lung cancer,1 pancreatic cancer,1 duodenal cancer,1 renal cancer,and 1 primary peritoneal cancer.All patients underwent whole-body PET/CT imaging by using 18F-FAPI and 18F-FDG tracers.The detection rate and(maxi-mum standardized uptake value,SUVmax)of PC and PCI were determined by analyzing both two PET/CT images of each patient.A head-to-head comparison was conducted using the independent-sample t test.Results The detection rate of 18 F-FAPI PET/CT in PC was significantly higher than in 18F-FDG PET/CT(P＜0.001).In semi-quantitative analysis,the SUVmax of 18F-FAPI PET/CT was significantly higher than 18F-FDG PET/CT(t=6.498,P＜0.001).Among them,the SUVmax of 18F-FAPI PET/CT in patients with peritoneal metastases from ovarian and gastric cancers was significantly higher than 18F-FDG PET/CT(ovarian cancer:t=6.165,P＜0.001;gastric cancer:t=4.747,P=0.001).In visual a-nalysis,the PCI of peritoneal cancer lesions in 18F-FAPI PET/CT images was significantly higher than that in 18 F-FDG PET/CT(t=4.378,P＜0.001).Conclusion The diagnostic efficiency of 18F-FAPI PET/CT is demonstrated to be superior to that of 18F-FDG PET/CT in the diagnosis of peritoneal carcinomas,particularly in cases of peritoneal metasta-ses originating from gastric and ovarian cancers.
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