2020-2022年湖南省326 824名宫颈癌筛查和健康体检者HPV感染率及亚型分布
HPV infection rate and subtype distribution among 326 824 cervical cancer screening and health check ups in Hunan Province from 2020 to 2022
陈少强 1吴颖 2谢艳 2郭俊龙 1李菁 1谢小兵 1李萍1
作者信息
- 1. 湖南中医药大学第一附属医院医学检验与病理中心,湖南长沙 410007
- 2. 长沙迪安医学检验所有限公司PCR室,湖南长沙 410007
- 折叠
摘要
目的 分析湖南省女性人乳头瘤病毒(HPV)感染情况以及HPV亚型与宫颈上皮细胞和组织病理改变的关系,为当地HPV流行病学提供数据支持.方法 采集2020-2022年湖南省326 824名参加宫颈癌筛查和健康体检人群的宫颈脱落上皮细胞,采用荧光PCR技术检测其HPV分型,统计分析不同年龄、地区各HPV分型感染状况;其中9 940例进行液基薄层细胞学检查(TCT)检查或病理学检查,分析其HPV感染情况与细胞病理学阳性结局的关系.结果 HPV总体感染率为10.9％(35 646/326 824),其中单一型感染占81.9％(29 201/35 646),多重型感染占18.1％(6 445/35 646);单一型占比前 6 位型别依次为 HPV52(20.5％)、HPV58(16.0％)、HPV16(12.9％)、HPV53(11.9％)、HPV81(8.7％)和HPV70(8.6％).≥60岁组感染率最高,为15.7％(3 672/23 315),HPV感染阳性人群中,不同年龄组多重型感染占比总体差异有统计学意义,x2=365.910,P＜0.001.按病例来源划分,感染率最高的地区为张家界市[13.1％(2 089/15 982)],最低的地区为永州市[8.7％(3 219/37 058)].单一型感染者组织和细胞学阳性率为47.1％(3 618/7 683),多重型感染者阳性率为 58.8％(1 326/2 257),x2=94.867,P＜0.001.在 7 683 例单一型 HPV 感染者中,HPV39、HPV66、HPV16、HPV6、HPV33、HPV42、HPV59 和 HPV58 组织和细胞学阳性率均超过 50％.结论 ≥60 岁人群HPV感染率最高,应加强对这一人群HPV感染的防治力度;HPV52和HPV58是全部人群中最为常见的型别;多重型HPV感染更可能导致宫颈疾病的发生.
Abstract
Objective To analyze the infection status of human papillomavirus(HPV)in women in Hunan Province,as well as the relationship between HPV subtypes and pathological changes in cervical epithelial cells and tissues,to provide data support for local HPV epidemiology.Methods A total of 326 824 cervical epithelial cells from the population participating in cervical cancer screening and health examinations in Hunan Province from 2020 to 2022 were collected.Using fluores-cence PCR technology to detect their HPV typing,and statistically analyze the HPV infection status of different age groups and regions;Among them,9 940 cases underwent thin-prep cytology test or pathological examination to analyze the relationship between their HPV infection status and positive results in cell pathology.Results The overall infection rate of HPV was 10.9％(35 646/326 824),with monotypic infection accounting for 81.9％(29 201/35 646)and multi se-vere infection accounting for 18.1％(6 445/35 646);The top 6 types with a single type proportion were HPV52(20.5％),HPV58(16.0％),HPV16(12.9％),HPV53(11.9％),HPV81(8.7％),and HPV70(8.6％).The infection rate in the ≥60 years old group was the highest[15.7％(3672/23 315)].Among the HPV positive population,there was a statistically significant difference in the proportion of multiple severe infections among different age groups,x2=365.910,P＜0.001.According to the source of cases,the highest infection rate was 13.1％(2 089/15 982)in Zhangjiajie City,and the lowest was 8.7％(3 219/37 058)in Yongzhou City.The positive rate of tissue and cytology in single type infections was 47.1％(3 618/7 683),while the positive rate in multiple severe infections was 58.8％(1 326/2 257),x2=94.867,P＜0.001.Among 7 683 cases of single type HPV infection,the positive rates of HPV39,HPV66,HPV16,HPV6,HPV33,HPV42,HPV59 and HPV58 in tissue and cytology were exceeded 50％.Conclusions HPV infection rate among people over 60 years old is the highest,and efforts should be strengthened to prevent and control HPV infec-tion in this population.HPV52 and HPV58 are the most common genotypes in the entire population.Multiple severe HPV infections are more likely to lead to the occurrence of cervical diseases.
关键词
人乳头瘤病毒/感染率/宫颈肿瘤/宫颈上皮内瘤样病变/湖南省Key words
human papillomavirus/infection rate/cervical tumors/cervical intraepithelial neoplasia/Hunan Province引用本文复制引用
基金项目
湖南省自然科学基金(2022JJ30455)
湖南省临床医疗技术创新引导项目(2021SK51409)
湖南省科技厅重点领域研发计划(2022GK2057)
出版年
2024
NETL
NSTL
万方数据