目的 总结蛋白质棕榈酰化的机制及与癌症发生发展的关系,通过分析棕榈酰化在消化系统肿瘤中的研究进展,探索靶向棕榈酰化过程用于消化系统肿瘤治疗方面的潜在策略.方法 以"棕榈酰化、翻译后修饰、消化系统肿瘤、肿瘤治疗"为中文检索词,以"protein palmitoylation、post-translational modification、digestive system cancer、tumor therapy"为英文检索词,检索PubMed和中国知网数据库2007年1月-2023年7月的相关文献.纳入标准:(1)棕榈酰化的生化反应机制和特点;(2)棕榈酰化过程与癌症相关机制;(3)棕榈酰化在消化系统肿瘤中的作用;(4)靶向棕榈酰化途径对于肿瘤治疗的潜在作用.排除标准:(1)研究机制模糊文献;(2)会议性和评论类文献;(3)内容相似或重复文献.最终共纳入符合条件文献70篇.结果 蛋白质棕榈酰化对于癌基因(如N-Ras和表皮生长因子受体)的功能至关重要.在调控蛋白质的转运、细胞定位和稳定性等方面都具有重要的作用,参与诸多生物学过程,并与消化系统肿瘤的发生发展关系密切.靶向棕榈酰化过程或联合肿瘤免疫治疗具有潜在治疗价值.结论 棕榈酰化在消化系统肿瘤的发生发展及侵袭转移中具有重要地位,并影响肿瘤免疫.棕榈酰化研究有望为消化系统肿瘤的治疗提供新靶点.
Research progress on the relationship between protein palmitoylation modification and digestive system cancer
Objective To summarize the mechanism of protein palmitoylation and its correlation with the occurrence and de-velopment of cancer,elucidate the research progress of palmitoylation in digestive system cancer,and explore the poten-tial strategies of targeting palmitoylation for the treatment of digestive system cancer.Methods With"protein palmitoyla-tion,post-translational modification,digestive system cancer,tumor therapy"as the keywords,the relevant literature of PubMed and CNKI was retrieved from January 2007 to July 2023.Inclusion criteria:(1)Biochemical reaction mechanism and characteristics of palmitoylation;(2)The mechanism of palmitoylation process and cancer;(3)The role of palmitoyla-tion in digestive system cancer;(4)The potential role of targeting palmitoylation pathways in tumor treatment.Exclusion criteria:(1)Literature on the study of ambiguous mechanisms;(2)Conference,commentary and other literature;(3)Similar or duplicate literature.A total of 70 eligible literature were included.Results Protein palmitoylation is essen-tial for the function of oncogenes such as N-Ras and epidermal growth factor receptor.It plays an important role in regu-lating protein transport,cell localization and stability,participates in many biological processes,and is closely related to the occurrence and development of digestive system cancer.Targeting palmitoylation processes may be of potential thera-peutic value in combination with tumor immunotherapy.Conclusions Protein Palmitoylation plays an important role in the occurrence,development,invasion and metastasis of digestive system cancer,and affects tumor immunity.Palmitoylation research is expected to provide a new target for the treatment of digestive system cancer.
protein palmitoylationpost-translational modificationdigestive system cancertumor therapyreview literature
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