Clinical significance of functional magnetic resonance imaging in identifying subventricular zone involvement in postoperative patients with high-grade gliomas
Objective To investigate the relationship between postoperative magnetic resonance functional imaging charac-teristics and the involvement of the subventricular zone(SVZ)in high-grade glioma(HGG).Methods Retrospective a-nalysis of 50 patients with HGG admitted to Jiangsu Provincial Cancer Hospital from 2018-01-01-2020-06-30,including 28 males and 22 females;age 22-73 years old,median age 53 years old.All enrolled patients underwent MRI functional imaging scans before radiotherapy,and the postoperative conventional MRI and functional MRI imaging of HGG patients were summarized.Imaging features of the patients were analyzed,with a specific focus on their correlation with SVZ in-volvement.Fisher's exact probability test was used to analyze the relationship between SVZ involvement,and logistic re-gression models were used for univariate and multivariate analysis.Results Among the 50 HGG patients included in the study,SVZ involvement was observed in 40 cases(80.0％),high perfusion changes in 26 cases(52.0％),and disruption or absence of peritumoral fiber tracts in 39 cases(78.0％).In the patients with surgical area T1 enhancement,15 cases(37.5％)had high perfusion areas,and 35 cases(87.5％)showed SVZ involvement.The presence of SVZ involvement in the surgical area of patients with T1 enhancement was significantly higher than in the patients without surgical area en-hancement(87.5％vs 50.0％,P=0.018).The incidence of SVZ involvement in the surgical area of patients with high perfusion was significantly higher than that in the patients without high perfusion(40.0％vs 0,P=0.020).The pres-ence of SVZ involvement in the surgical area of patients with disrupted peritumoral fiber tracts was significantly higher than that in the patients without fiber tract disruption(90.0％vs 30.0％,P=0.004).Multivariate analysis showed that disruption or absence of peritumoral fiber tracts and enhancement of the surgical area were risk factors for SVZ involve-ment(P＜0.05).Conclusions HGG imaging characteristics,such as enhancement of the surgical area,high perfusion within the surgical area,and disruption or absence of peritumoral fiber tracts,are associated with higher incidence of SVZ involvement.Disruption or absence of peritumoral fiber tracts and T1 enhancement of the surgical area are risk factors for SVZ involvement.
high-grade gliomasubventricular zonefunctional magnetic resonance imagingdiffusion tensor imagingper-fusion weighted imaging
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