胰腺癌有氧糖酵解相关代谢重塑的研究进展
Advances in metabolic reprogramming associated with aerobic glycolysis in pancreatic cancer
尹艳梅 1阮万百 1李俊峰 1彭磊 1朱克祥2
作者信息
- 1. 兰州大学第一临床医学院,甘肃兰州 730000
- 2. 兰州大学第一医院普外科,甘肃兰州 730000
- 折叠
摘要
目的 阐述胰腺癌有氧糖酵解相关代谢重塑过程的研究进展及以饮食为基础的特殊抗肿瘤方式.方法 以"糖酵解、瓦博格效应、胰腺癌、代谢重塑"为中文关键词,以"glycolysis、Warburg effect、pancreatic cancer、metabolic reprogram-ming"为英文关键词,检索2000年1月-2024年1月中国知网和Pubmed数据库相关文献.纳入标准:(1)有氧糖酵解的定义及作用;(2)胰腺癌糖酵解相关酶基因表达与酶活性变化;(3)针对有氧糖酵解相关介质的胰腺癌饮食防治策略.排除标准:(1)低质量文献;(2)数据陈旧文献;(3)会议摘要.最终共纳入46篇相关文献.结果 胰腺癌通过增加糖酵解相关酶的表达、打破糖酵解-氧化磷酸化平衡、诱导遗传学改变及影响肿瘤微环境等途径使代谢重塑向有氧糖酵解;并简要介绍了热量限制和生酮饮食2种特殊的肿瘤治疗方式.通过对有氧糖酵解过程中的腺嘌呤核苷三磷酸(ATP)和酮体等关键代谢介质进行研究,发现新的抗肿瘤方法,为胰腺癌开辟了新的路径.结论 胰腺癌有氧糖酵解相关的代谢重编程过程复杂,基于饮食的抗肿瘤治疗研究较少,亟需进一步探索.
Abstract
Objective To describe the research progress of aerobic glycolysis-related metabolic remodeling in pancreatic cancer and the special diet-based anti-tumor approach.Methods With"glycolysis,Warburg Effect,pancreatic cancer,met-abolic reprogramming"as the key words,the relevant literature of PubMed and China National Knowledge Infrastructure(CNKI)from January 2000 to January 2024.Inclusion criteria:(1)The definition and role of aerobic glycolysis;(2)The expression of glycolysis-related enzymes and the change of enzyme activity in pancreatic cancer;(3)Dietary strategies tar-geting aerobic glycolysis-related mediators for pancreatic cancer.Exclusion criteria:(1)Low-quality literature;(2)Data obsolescence literature;(3)Minutes.Finally,2 Chinese and 44 English literature were included.Results Pancreatic cancer alters metabolism towards aerobic glycolysis by upregulating glycolysis-related enzymes,disrupting the balance be-tween glycolysis and oxidative phosphorylation,inducing genetic mutations,and affecting the tumor microenvironment.Additionally,this text briefly describes two specific therapeutic approaches for treating pancreatic cancer.The study of key metabolic mediators,such as adenine nucleoside triphosphate(ATP)and ketone bodies,during aerobic glycolysis has led to the discovery of new anti-tumor approaches,opening up new pathways for the treatment of pancreatic cancer.Con-clusions The metabolic reprogramming processes associated with aerobic glycolysis in pancreatic cancer are complex.Di-et-based antitumor therapy has been less studied and needs to be further explored.
关键词
胰腺癌/有氧糖酵解/Warburg效应/基因突变/代谢重编程/肿瘤微环境Key words
pancreatic ductal adenocarcinoma/aerobic glycolysis/Warburg effect/gene mutation/metabolic reprogram-ming/tumor microenvironment引用本文复制引用
基金项目
国家自然科学基金(81960516)
甘肃省自然科学基金(21JR7RA359)
出版年
2024
NETL
NSTL
万方数据