Current status of tumor-like organ biospecimen banking
Objective To review the current research status of tumor organoids biobanks and explore their application value in cancer research and clinical treatment.Methods Using"tumor organoids,organoids biobank,cancer research,clinical treatment"as keywords,we searched PubMed and China Knowledge Network(CNN)from January 2018 to December 2023 for the current research status of biobanks of tumor-like organs,the construction of tumor organoid biobanks,their advantages and their applications in drug screening,individualized therapy and immunotherapy.Inclusion criteria:(1)the construction methods and techniques of tumor-like organ biobanks;(2)the advantages of tumor-like organs in preserving the characteristics of primary tumor tissues;(3)studies on drug screening and therapeutic strategies based on tumor-like organ biobanks.Exclusion criteria:(1)literature only involving other types of class organs and not related to tumors;(2)literature with duplicated studies or low quality.A total of 66 papers were finally included.Results Tumor organoid biobanks,as a novel tool for cancer research,are able to highly reproduce the characteristics of primary tumors,which provides a powerful support for high-throughput drug screening and the development of individualized treatment plans.Meanwhile,tumor organoid biobanks also contribute to the in-depth study of tumor evolution and heterogeneity.Conclu-sion Tumor organoid biobanks are important resources for tumor research and clinical treatment,and have a wide range of application prospects.In the future,with the continuous progress and improvement of technology,tumor organoid biobanks will play a greater role in the field of precision medicine such as tumor.
NETL
NSTL
万方数据
