Relationship between lipiodol deposition in portal vein tumour thrombus and prognosis in patients with primary hepatic cancer complicated with portal vein tumor thrombosis
Objective To investigate the association of lipiodol deposition in portal vein tumor thrombus(PVTT)with the survival time,quality of life and clinical complications in patients who have primary hepatic cancer(PHC)complicated with PVTT after transcatheter arterial chemoembolization(TACE)combined with targeted drugs.Methods Retrospec-tive analysis was performed in 74 patients who have primary hepatic cancer complicated with PVTT in the Department of Interventional of Shandong Cancer Hospital from May 1,2015 to April 3,2019 and Jining First People's Hospital from January 1,2018 to December 2,2019.The patients were divided into two groups by the deposition of lipiodol in PVTT,with 39 cases in the well-deposited lipiodol group(group A)and 35 cases in the poor or no deposition group(group B).Progression free survival(PFS),overall survival(OS),and incidence of clinical complications were compared between the two groups.Results The median OS of the group A was 29(21.1-36.9)months,and the median OS of the group B was 9(5.8-12.2)months.There was a statistically significant difference in mortality rates at various time points of OS be-tween the two groups(x2=26.308,P＜0.001).The median PFS of the group A was 19(15.4-22.6)months,and the median PFS of the group B was 6(2.6-9.4)months(x2=19.766,P＜0.001).The incidence rate of complication in the group A was 74.4％and 68.6％in Group B.The incidence of complication of the two groups did not differ significantly(x2=0.304,P=0.615).The test result showed the OS difference of the two groups for PVTT type Ⅰ at every time point was statistically significant(x2=4.174,P=0.041).The result showed the PFS difference of the two groups for PVTT type Ⅱ at every time point was statistically significant(x2=4.119,P=0.042),and there was a statistically significant difference in OS mortality rates at various time points between the two groups of PVTT type Ⅱ(x2=3.092,P=0.048).The PFS and OS differences of the two groups for PVTT type Ⅲ+Ⅳ at every time point were statistically significant(x2=24.784,P＜0.001;x2=24.013,P＜0.001).Conclusion Lipiodol deposition of tumor thrombus is a major factor af-fecting the prognosis of patients,and patients with good deposition have satisfactory prognosis.Also,it is not significantly associated with the incidence of complications.The type of PVTT can make differences to the PFS and OS of patients with good and poor lipiodol deposition.
NETL
NSTL
万方数据
