摘要
目的 总结钙结合蛋白S100家族的生物学特性,探讨在非小细胞肺癌(NSCLC)中的表达和作用机制,以及在NSCLC诊断、治疗和判断预后中的应用前景.方法 以"S100、非小细胞肺癌、作用机制、诊断、预后"为中文检索词,以"S100、non-small cell lung cancer、mechanism、diagnosis、prognosis"为英文检索词,系统检索 PubMed 及中国知网数据库2005-01-01-2023-07-01发表的相关文献,纳入标准:(1)S100蛋白的生物学特性及功能;(2)调节S100蛋白表达对肺癌细胞的影响;(3)S100蛋白表达水平对肺癌患者疗效及预后的影响.排除标准:(1)数据不完整的文献;(2)结果重复的文献;(3)与本研究关联性较低的文献.最终纳入符合条件参考文献52篇.结果 在众多S100蛋白家族中,S100A2、S100A4、S100A7、S100A8/A9、S100A13和S100P在NSCLC中表达上调,具有促癌作用,与较高的恶性程度、极易出现复发转移以及不良的预后密切相关.结论 S100蛋白家族与肺癌发生发展密切相关,可为NSCLC诊断、治疗提供新思路.
Abstract
Objective To summarise the biological properties of the S100 family of calcium-binding proteins,and to explore their expression and mechanism of action in non-small cell lung cancer(NSCLC),as well as their application in the diagno-sis,treatment and prognosis of NSCLC.Methods With"S100,non-small cell lung cancer,mechanism of action,diagnosis,prognosis"as the keywords,a systematic search of the PubMed and CNKI databases was conducted for relevant literature published from January 1,2005 to July 1,2023.Inclusion criteria:(1)Biological characteristics and functions of S100 pro-teins;(2)The impact of regulating S100 protein expression on lung cancer cells;(3)The influence of S100 protein expres-sion levels on the efficacy and prognosis of lung cancer patients.Exclusion criteria:(1)Literature with incomplete data.(2)Literature with duplicated results.(3)Literature with low relevance to this study.Finally,52 eligible articles were in-cluded.Results Among numerous S100 protein families,S100A2,S100A4,S100A7,S100A8/A9,S100A13,and S100P are upregulated in NSCLC and have a pro cancer effect.They are closely related to higher malignancy,susceptibility to recur-rence and metastasis,and poor prognosis.Conclusion The S100 protein family is closely related to the occurrence and de-velopment of lung cancer,and can provide new ideas for the diagnosis and treatment of NSCLC.
基金项目
山东省中医药科技重点项目(2020Z31)
山东省中医药科技青年项目(2020Q75)
青岛市医药卫生科研计划项目(2021-WJZD034)
吴阶平医学基金会临床科研专项基金(320.6750.2021-2-93)
NETL
NSTL
万方数据