Advances in the relationship between S100 family proteins and non-small cell lung cancer
Objective To summarise the biological properties of the S100 family of calcium-binding proteins,and to explore their expression and mechanism of action in non-small cell lung cancer(NSCLC),as well as their application in the diagno-sis,treatment and prognosis of NSCLC.Methods With"S100,non-small cell lung cancer,mechanism of action,diagnosis,prognosis"as the keywords,a systematic search of the PubMed and CNKI databases was conducted for relevant literature published from January 1,2005 to July 1,2023.Inclusion criteria:(1)Biological characteristics and functions of S100 pro-teins;(2)The impact of regulating S100 protein expression on lung cancer cells;(3)The influence of S100 protein expres-sion levels on the efficacy and prognosis of lung cancer patients.Exclusion criteria:(1)Literature with incomplete data.(2)Literature with duplicated results.(3)Literature with low relevance to this study.Finally,52 eligible articles were in-cluded.Results Among numerous S100 protein families,S100A2,S100A4,S100A7,S100A8/A9,S100A13,and S100P are upregulated in NSCLC and have a pro cancer effect.They are closely related to higher malignancy,susceptibility to recur-rence and metastasis,and poor prognosis.Conclusion The S100 protein family is closely related to the occurrence and de-velopment of lung cancer,and can provide new ideas for the diagnosis and treatment of NSCLC.
S100 protein familynon small cell lung cancerproliferationprognosisreview literature
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