Research progress of the mechanism of peroxisome proliferator-activated receptor γ in hepatocellular carcinoma
Objective To analyze the mechanism and potential value of peroxisome proliferator-activated receptor γ(PPARγ)in the precancerous and developmental stages of hepatocellular carcinoma(HCC),in order to provide new ideas for liver cancer prevention,precision therapy and drug exploration.Methods"Hepatocellular carcinoma,PPARγ,Precan-cerous lesions,Cancer development,Mechanism of action,Treatment progress"were used as keywords,to search PubMed and CNKI related literature.The search period was from 2005-01-01 to 2023-10-01.The inclusion criteria were:(1)Cur-rent diagnosis and treatment of HCC;(2)Study on the mechanism of PPARγ intervention in the precancerous stage of HCC;(3)Study on the mechanism of PPARγ intervention in the development stage of HCC;(4)Drug research on the treatment of liver cancer and its precancerous lesions based on PPARγ.Exclusion criteria:(1)Cases,conferences and criti-cal articles;(2)Articles with incomplete data;(3)Articles whose research mechanism was unclear and controversial.A to-tal of 57 articles were included according to the inclusion criteria.Results PPARγ is involved in improving the local in-flammatory microenvironment of liver,inhibiting liver fibrosis and the proliferation and differentiation of liver cancer stem cells,and promoting the expression of precancerous tumor suppressor genes.In the development stage after liver cancer formation,PPARγ promotes the glucose and lipid metabolism of cancer cells,induces angiogenesis,and reduces immuno-suppression.Taking PPARγ as the therapeutic target to explore different stage drugs used in the treatment of HCC may be a new direction for the implementation of liver cancer prevention and precision therapy.Conclusion PPARγ plays a regulatory role in different stages of hepatocellular carcinoma development,and further study on PPARγ is helpful to pro-vide new ideas for prevention and treatment of HCC.
hepatocellular carcinomaperoxisome proliferator-activated receptorspre cancerous lesionscancer develop-mentreview literature
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