癌基因YAP和TAZ与胰腺恶性肿瘤生物学行为及其预后的关系
Relationship of oncogene YAP and TAZ with biological behavior and prognosis of pancreatic malignant tumors
焦志超 1杨淑萍1
作者信息
- 1. 山东第一医科大学附属省立医院肿瘤微创综合治疗科,山东济南,250021
- 折叠
摘要
目的 探索胰腺导管腺癌(PDAC)组织中YAP/TAZ表达与临床病理指标的关系,分析YAP/TAZ与根治术后患者预后的关系.方法 分析178例公开数据癌症基因组图谱(TCGA)队列PDAC患者有关YAP/TAZ转录组学数据,并回顾性分析2015-12-25-2018-07-02于山东省立医院行胰腺肿瘤切除术的86例PDAC患者临床信息,通过YAP/TAZ免疫组化染色对术后病理标本进行评分.采用Kaplan-Meier方法和Cox比例风险模型分析YAP/TAZ与根治术后患者预后的关系.结果 86例患者中26例(30.23％)患者YAP强阳性,40例(46.51％)患者TAZ强阳性.YAP强阳性患者与YAP弱阳性患者1年生存率分别为30.8％和48.3％,2年生存率分别为11.5％和20.0％,P=0.021,YAP强阳性与较差的生存率有关(P=0.021),且YAP阳性综合评分为影响PDAC患者预后生存的危险因素(P=0.029,HR=1.707,95％CI:1.056～2.759);YAP强阳性表达与患者远处转移(P=0.020)和神经侵犯(P=0.036)有关联.结论 YAP是PDAC中有价值的预后生物标志物,与根治术后PDAC患者的生存期有关,且YAP表达水平与PDAC患者是否发生远处转移和神经侵犯有关联.
Abstract
Objective To explore the correlation between the expression of YAP/TAZ in pancreatic ductal adenocarcinoma(PDAC)tissue and clinicopathological indicators,and analyze the relationship between YAP/TAZ and the prognosis of PDAC patients after radical resection.Methods Publicly available YAP/TAZ transcriptomics data were retrieved from 178 PDAC patients from The Cancer Genome Atlas(TCGA).The clinical information of 86 PDAC patients who under-went pancreatic tumor resection in Shandong Provincial Hospital from December 25,2015 to July 2,2018 were retrospec-tively analyzed,and the postoperative pathological specimens were scored by YAP/TAZ immunohistochemical staining.The prognostic correlation of YAP/TAZ was analyzed by the Kaplan-Meier method and multivariate Coxproportional haz-ards model.Results Among 86 patients,26 patients(30.23％)were strongly positive for YAP,and 40 patients(46.51％)were strongly positive for TAZ.The 1-year survival rates of patients with strong YAP positivity and those with weak YAP positivity were 30.8％and 48.3％respectively,and the 2-year survival rates were 11.5％and 20.0％respec-tively,P=0.021.Strong YAP positivity was related to poor survival rate(P=0.021),and YAP positive comprehensive score was a risk factor affecting the prognosis and survival of PDAC patients(P=0.029,HR=1.707,95％CI:1.056～2.759);strong YAP positive expression was associated with patients with distant metastasis(P=0.020),nerve invasion(P=0.036).Conclusions YAP is a valuable prognostic biomarker in PDAC,which is related to the survival of PDAC pa-tients after radical surgery,and the expression level of YAP is associated with the occurence of distant metastasis and nerve invasion in PDAC patients.
关键词
胰腺导管腺癌/YAP/TAZ/预后/神经侵犯Key words
pancreatic ductal adenocarcinoma/YAP/TAZ/prognosis/perineural invasion引用本文复制引用
出版年
2024
NETL
NSTL
万方数据