Analysis of the disease burden of cancer in children aged 0-14 years in China from 1990 to 2019 and its changing trend
Objective To investigate the changing trend and main sources of pediatric cancer disease burden in 0-14 year old children in China from 1990 to 2019.Methods Data from Global Health Data Exchange(GHDx)database were used to analyze the incidence,mortality and disability-adjusted life year(DALY)rates of pediatric cancer in China and the world from 1990 to 2019 by sex and age.The Joinpoint method was used to analyze the annual percentage change(APC)and av-erage annual percentage change(AAPC)in pediatric cancer incidence,mortality and DALY rates.Results From 1990 to 2019,all indicators of the burden of childhood tumor disease in China showed a downward trend,with the average annual change of incidence rate of-3.28％(-3.61％,-2.95％),the average annual change of mortality rate of-3.29％(-3.53％,-3.05％),and the average annual change of DALY rate of-3.29％(-3.52％,-3.05％),all P＜0.001;The overall trend of each indicator was divided into 6 sections.The incidence rate decreased by 6.58％,the years of lived with disability(YLD)rate decreased by 22.89％,which were lower than the global overall decrease rate,the mortality rate decreased by 62.17％,the DALY rate decreased by 62.04％,and the years of life lost(YLL)rate decreased by 60.7％,which were higher than the global overall decrease rate.The incidence in China was at a low level,but the mortality and DALY rates were much higher than those in developed countries such as the United States.Among all age groups,the indexes of disease burden in 0-28 d group were the highest,and the indexes showed a decreasing trend with the increase of age.There were gender differences in disease burden indicators.In China,leukemia was the highest in in-cidence,mortality,and DALY rates of childhood tumors,and the order of incidence rates in childhood cancer exhibited a gender difference.Conclusions The burden of cancer in children in China showed a decreasing trend from 1990 to 2019.Premature death was the main source of the burden of cancer,and there were gender and age differences in the burden.
pediatric tumordisease burdendisability adjusted life yearstrends of changeburden of disease
NETL
NSTL
万方数据
