放免联合时序在食管癌中的研究进展
Progress of radioimmunoassay combined with timing in esophageal cancer
魏卓隽 1汪琳 1王瑞琪 2王雨 3陈焕 2徐裕金4
作者信息
- 1. 绍兴文理学院医学院,浙江绍兴 312000;浙江省肿瘤医院胸部放疗科,中国科学院杭州医学研究所,浙江杭州 310022
- 2. 浙江省肿瘤医院胸部放疗科,中国科学院杭州医学研究所,浙江杭州 310022;温州医科大学研究生培养基地(浙江省肿瘤医院),浙江温州 325035
- 3. 浙江省肿瘤医院胸部放疗科,中国科学院杭州医学研究所,浙江杭州 310022;浙江中医药大学第二临床医学院,浙江杭州 310053
- 4. 浙江省肿瘤医院胸部放疗科,中国科学院杭州医学研究所,浙江杭州 310022
- 折叠
摘要
目的 总结食管癌放免联合的相关研究,探讨放免联合的时序问题.方法 以食管肿瘤、放射治疗、免疫检查点抑制剂、时序等为中文关键词,以"Esophageal cancer、Radiotherapy、Immune checkpoint inhibitors、Sequence"为英文关键词,检索PubMed、CNKI和百链数据库2011-2022年相关文献.纳入标准:(1)放疗联合免疫治疗机制;(2)食管癌放射和免疫联合治疗.排除标准:(1)数据陈旧文献;(2)内容相似或重复.最终纳入文献49篇.结果 基础研究表明,放疗联合免疫治疗可以通过改善肿瘤微环境、诱导免疫抗原暴露、增加肿瘤细胞含氧量等方式增强对肿瘤细胞的杀伤作用.食管癌临床试验表明,无论放疗前免疫还是放疗后免疫均对患者产生生存获益.结论 放疗联合免疫治疗可改善食管癌患者预后且安全性良好,而最佳的联合时序仍有待探讨.
Abstract
Objective To summarize studies related to radiation-immunity combinations in esophageal cancer and to explore the timing of radiation-immunity combinations.Methods PubMed database,CNKI database,and BaiLian database were searched by using the keywords"Esophageal cancer,Radiotherapy,Immune checkpoint inhibitors,Sequence"for relevant literature from 2011 to 2022.Inclusion criteria:(1)radiotherapy combined with immunotherapy as the mechanism of treatment;(2)combined radiotherapy and immunotherapy for esophageal cancer.Exclusion criteria:(1)literature with obsolete data;(2)content similarity or duplication.A total of 49 papers were finally included.Results Basic research has shown that radiotherapy combined with immunotherapy can enhance the killing effect on tumor cells by improving the tumor microenvironment,inducing immune antigen exposure,and increasing the oxygen content of tumor cells.Clinical trials in esophageal cancer have shown that both immunotherapy prior to radiotherapy and immunotherapy after radiation therapy produce survival benefits for patients.Conclusion Radiotherapy combined with immunotherapy can significantly improve the prognosis of patients with esophageal cancer and has a positive safety profile,while the sequence of combina-tion remains to be explored.
关键词
食管肿瘤/放射治疗/免疫检查点抑制剂/时序/综述文献Key words
esophageal cancer/radiotherapy/immune checkpoint inhibitors/sequence/review literature引用本文复制引用
基金项目
浙江省基础公益研究计划(LGF21H160005)
浙江省卫生健康科技计划(2022KY106)
出版年
2024
NETL
NSTL
万方数据