Progress of radioimmunoassay combined with timing in esophageal cancer
Objective To summarize studies related to radiation-immunity combinations in esophageal cancer and to explore the timing of radiation-immunity combinations.Methods PubMed database,CNKI database,and BaiLian database were searched by using the keywords"Esophageal cancer,Radiotherapy,Immune checkpoint inhibitors,Sequence"for relevant literature from 2011 to 2022.Inclusion criteria:(1)radiotherapy combined with immunotherapy as the mechanism of treatment;(2)combined radiotherapy and immunotherapy for esophageal cancer.Exclusion criteria:(1)literature with obsolete data;(2)content similarity or duplication.A total of 49 papers were finally included.Results Basic research has shown that radiotherapy combined with immunotherapy can enhance the killing effect on tumor cells by improving the tumor microenvironment,inducing immune antigen exposure,and increasing the oxygen content of tumor cells.Clinical trials in esophageal cancer have shown that both immunotherapy prior to radiotherapy and immunotherapy after radiation therapy produce survival benefits for patients.Conclusion Radiotherapy combined with immunotherapy can significantly improve the prognosis of patients with esophageal cancer and has a positive safety profile,while the sequence of combina-tion remains to be explored.
esophageal cancerradiotherapyimmune checkpoint inhibitorssequencereview literature
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