Research progress of nanomedicine delivery system in the treatment of gastric cancer
Objective To review the research status of nanomedical drug delivery system in the treatment of gastric cancer,and explain its mechanism of action in the treatment of gastric cancer,which can provide reference for the future research prospect and clinical application potential of nanomedical drug delivery system in the treatment of gastric cancer.Methods With"Nanomedicine Delivery System,Gastric cancer,Treatment"as the keywords,the relevant literature of PubMed and CNKI were retrieved from December 2009 to December 2023.Inclusion criteria were as follows:(1)relevant animal experiments;(2)relevant clinical trials;(3)study on the mechanism of nano drug delivery system in the treatment of gastric cancer;(4)nano-drug delivery system carriers used in the treatment of gastric cancer;(5)the value and appli-cation status of nano-drug delivery system in the treatment of gastric cancer;(6)clinical transformation of nano-drug de-livery system in the treatment of gastric cancer.Exclusion criteria were:(1)articles with similar or repeated content;(2)the research mechanism is ambiguous and controversial.A total of 74 literatures were included.Results The thera-peutic mechanism of gastric cancer based on nano drug delivery system is mainly to improve drug targeting,delay drug circulation time in the body,reduce drug degradation in gastric acid environment,regulate the level of reactive oxygen species in gastric cancer cells,and enhance the anti-tumor immune response.Based on this,the nano-drug delivery system can realize multi-drug delivery,delay drug resistance,promote combined application,reduce side effects,enhance preop-erative and intraoperative image guidance,and thus enhance efficacy,providing a promising solution strategy for the shortcomings of current drug therapy for gastric cancer such as poor efficacy of single drug,many side effects,and easy drug resistance.Conclusion With the development of novel nanomedical drug delivery system and the development of a number of animal and clinical trials based on nanomedical drug delivery system therapy,nanomedical drug delivery system has emerged in the treatment of gastric cancer.
nanomedicine delivery systemgastric cancertreatmentreview literature
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