Progress in tumor vaccines and cell therapies targeting shared neoantigens
Shared neoantigens are immunogenic epitopes that are commonly found in tumor patients and are usually genera-ted by hotspot mutations in tumor driver genes.They are expressed only in tumor tissues and act as tumor-specific anti-gens to stimulate an immune response.Shared neoantigens are favored by researchers because of their"off-the-shelf"avail-ability,universality,highly specificity,and strong immunogenicity.This review describes in detail the sources,characteris-tics and common shared neoantigens,focusing on the research progress of novel therapeutic methods such as vaccine thera-py and cell therapy targeting shared neoantigens.Also,this article lists the relevant clinical trials,and briefly describes the strategies to improve the vaccine and cell therapy against shared neoantigens.
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