Research progress of anti-tumor drugs targeting trophoblast cell surface antigen 2
Objective To investigate the structure of trophoblast cell surface antigen 2(Trop 2)and its signaling pathways involved in tumor proliferation,migration,invasion and metastasis,and the development of anti-tumor drugs targeting Trop 2.Methods The key words such as"Trop 2,targeted therapy,tumors,antibody-drug conjugates,radioimmunotherapy"were retrieved in CNKI,PubMed databases,mainly focusing on the related literature from 1997 to 2023.The criteria for selection were:(1)The structure and function of Trop 2;(2)Antibody-drug conjugates targeting Trop 2;(3)Radiolabeled drugs targeting Trop 2;(4)Photoimmunotherapy targeting Trop 2.The exclusion criteria were:(1)Poor correlation with tumor;(2)Unfull text;(3)Pre-clinical ADC drugs,and 65 articles were included.Results Trop 2 is a transmembrane protein that not only serves as a predictive factor for various types of cancer,controlling cell growth and diffusion through various signaling pathways,but also has high ex-pression on the surface of various solid tumor cells and extremely low expression in normal tissues.ADCs targeting Trop 2 mainly include Sacituzumab govitecan,Datopotamab,deruxtecan(DS-1062),SKB-264,DAC-002(JS-108),ESG-401,FDA018,BAT-8003 and RN927C(PF-06664178),which are mainly used to treat advanced or metastatic triple negative breast cancer,upper u-rinary tract cancer,non small cell lung cancer,breast cancer,gastric cancer,small cell lung cancer,pancreatic cancer and other solid tumors.The non ADC drugs targeting Trop 2 mainly include(Rap)2-E1-(Rap)2,radiopharmaceuticals,and photoimmuno-therapy.Trop 2 has become a new target for precision medicine,such as drugs synthesized by coupling radioactive isotopes,tox-ins,and specific antibodies.Conclusion The research on anti-tumor drugs targeting Trop 2 has made some achievements in ADCs,radiopharmaceuticals,photoimmunotherapy.At present,several drugs have been approved for marketing or are in clini-cal trials.At the same time,the drug combination therapy targeting Trop 2 shows a good research prospect.
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