Influencing factors analysis of malignant ventricular arrhythmias in refractory heart failure using a competitive risk model
Objective To analyze the influencing factors of refractory heart failure(RHF)complicated with malignant ventricular arrhythmias using a competitive risk model.Methods A retrospective analysis was conducted on the clinical data of 573 patients with RHF who were treated in our hospital from January 2019 to May 2023.The incidence rates of malignant ventricular arrhythmias(target event),mortality before malignant ventricular arrhythmias(competitive event),and neither malignant ventricular arrhythmias nor mortality(deleted event)were followed up and statistically analyzed.The Fine-Gray competitive risk model was used to analyze the influencing factors of malignant ventricular arrhythmias in RHF patients.Results The median follow-up time for the 573 RHF patients was 7(0.5～37)months.The incidence rate of malignant ventricular arrhythmias was 58.99%,the incidence rate of competitive events was 12.39%,and the incidence of deleted events was 28.62%.There were statistically significant differences in age,history of diabetes,history of hypertension,New York Heart Association(NYHA)classification,systolic blood pressure,left ventricular ejection fraction(LVEF),left ventricular end diastolic diameter(LVEDD),N-terminal pro brain natriuretic peptide(NT-proBNP),and blood potassium among different outcome events(P<0.05).Single-factor analysis using the Fine-Gray competitive risk model showed that the history of diabetes,hypertension,LVEF,LVEDD,NT-proBNP,and blood potassium were risk factors for malignant ventricular arrhythmias in RHF(P<0.05).Further multivariate analysis revealed that hypertension,LVEF,LVEDD,NT-proBNP,and blood potassium were independent influencing factors of malignant ventricular arrhythmias in RHF(P<0.05).Conclusions Under the analysis of the competitive risk model,hypertension,LVEF,LVEDD,NT-proBNP,and blood potassium are all independent influencing factors of malignant ventricular arrhythmias in RHF.
Refractory heart failureVentricular arrhythmiaInfluencing factorsCompetitive risk model
万方数据
维普
