Analysis of correlation between microcirculation changes around the optic disc and retinal nerve fiber layer thickness in patients with diabetic retinopathy
Objective To apply swept-source optical coherence tomography angiography(SS-OCTA)and compare the changes in peripapillary optic disc microcirculation and retinal nerve fiber layer thickness related to diabetic retinopathy among age-matched healthy subjects and patients with diabetic retinopathy.Methods A total of 158 patients treated in the ophthalmology and endocrinology departments of the First Affiliated Hospital of Anhui University of Science and Technology from June to September 2023 were enrolled in a cross-sectional study.Based on the Early Treatment Diabetic Retinopathy Study(ETDRS)guidelines,the participants were divided into three groups:control group(53 patients),no diabetic retinopathy group(NDR,53 patients),and non-proliferative diabetic retinopathy group(NPDR,52 patients).Three indices were measured and comparatively analyzed using the SS-OCTA technique in each sector of the peripapillary optic disc:retinal vessel density(RVD),perfusion density(PD),and peripapillary retinal nerve fiber layer(pRNFL)thickness.Results Compared with the control group,the differences in RVD and PD in the four quadrants in the NDR group were not statistically significant(P>0.05).In the NPDR group,changes in RVD were statistically significant in all quadrants except the N quadrant(P<0.05).The pRNFL thickness was thicker in the NDR group compared to the control group(P<0.05),while there was no significant difference in pRNFL thickness between the NPDR group and the control group(P>0.05).The peripapillary RVD was moderately positively correlated with pRNFL thickness in the control group(r=0.7645,P<0.0001),in the NDR group(r=0.5252,P<0.0001),and in the NPDR group(r=0.4652,P=0.001).Similarly,peripapillary PD was moderately positively correlated with pRNFL thickness in the control group(r=0.7587,P<0.0001),in the NDR group(r=0.5695,P<0.0001),and in the NPDR group(r=0.5895,P=0.0003).Conclusions In the development of diabetic retinopathy,changes in PD and RVD in each quadrant may be consistent.In the early stages of diabetic retinopathy,pRNFL is significantly thinner,suggesting that pRNFL may be a marker of retinal vascular and neurologic damage.SS-OCTA is valuable in assessing microcirculatory changes in early diabetic retinopathy.
万方数据
维普
