Clinical value of C-reactive protein to albumin ratio in early prediction of severity of acute pancreatitis
Objective To investigate the clinical value of the C-reactive protein(CRP)to albumin(Alb)ratio(CAR)in the early prediction of the severity of acute pancreatitis.Methods Retrospectively analyzed the clinical data of 83 hospitalized patients diagnosed with acute pancreatitis(AP)from September 2019 to June 2022.Patients were divided into two groups:moderately severe acute pancreatitis(MSAP)+severe acute pancreatitis(SAP)group(29 cases)and mild acute pancreatitis(MAP)group(54 cases).General conditions and laboratory indices were compared between the two groups.Univariate analysis was used to identify factors associated with MSAP+SAP,and multiple logistic regression analysis was performed to estimate the independent risk factors for early prediction of MSAP+SAP.The receiver operating characteristic curve(ROC)was used to evaluate the early predictive value of CAR for MSAP+SAP.Results Univariate analysis revealed significant differences in white blood cell counts and neutrophil granulocyte(N)counts between the MSAP+SAP and MAP groups(all P<0.05).Compared with the MAP group,the MSAP+SAP group had significantly higher levels of amylase,lipase,CRP,triglycerides,NLR,and CAR,while albumin and serum calcium ion concentrations were significantly lower,with statistically significant differences between groups(all P<0.05).Multiple logistic regression analysis indicated that CAR(OR 1.697,95%CI 1.229～2.344,P=0.001)was an independent risk factor for MSAP+SAP.ROC curve analysis showed that CAR had a good predictive value for MSAP+SAP,with a sensitivity of 72.4%,specificity of 98.1%,and an area under the ROC curve(AUC)of 0.906 at a cut-off value of 4.41.Conclusions CAR can be used as a marker for the early prediction of MSAP+SAP.
Acute pancreatitisModerately severe and severeC-reactive protein to albumin ratioPrediction
万方数据
维普
