Synthesis of Seven-membered Ring Compound from Conjugate Ynone by Cascade Reaction
Cascade annulation enables the rapid and efficient construction of complex structural chemicals,thus greatly improving the atomic economy and reducing the by-procuct from multi-chemical processes.The structure of the seven-membered ring is mostly found in drug molecules or natural products,which still pose a challenge in synthesis.Con-jugated ynone has high reactivity and a variety of reaction modes due to its special structure.The methods of conjugated acetylenic ketones—ones that were adopted during the period from 2019 to 2023—for the efficient construction of ben-zoxaheptadecane,benzazepine heptadecane,heptadecanol and cycloheptadecanone skeletons via tandem cycloaddition reac-tions catalyzed by a variety of bases,phosphine reagents,gold chloride catalysts,and oxidizing agents were reviewed to pro-vide an important reference to explore the reactivity of acetylenic ketones and to construct the seven-membered ring struc-tures.
cascade annulationconjugated ynoneseven-membered ring compound
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