Report of one case of coccidioidomycosis with literature review
This paper reports a case of coccidioidomycosis caused by Coccidioides posadasii.The patient was admitted due to fever,cough and phlegm,skin rash visible on the head,face and body with pus inside.Laboratory tests presented white blood cell count of 14.25×109/L,an absolute value of 2.64×109/L for eosinophils,and 85.9 mg/L for hypersensi-tive C-reactive protein.Chest CT exposed a nodular shadow in the lower lobe of the right lung,with multiple enlarged lymph nodes in the mediastinum.The symptoms were not relieved after anti-infection and symptomatic medication.Metagenomics next-generation sequencing(mNGS)was performed on the skin tissue,purulent pus,and peripheral ve-nous blood.The diagnosis of mNGS was confirmed as disseminated coccidioidomycosis,and the symptom was signifi-cantly improved after antifungal treatment.This article retrospectively analyzed the case data and searched for relevant literatures to investigate the clinical characteristics,diagnostic evidences,and treatment measures for this disease,with the diagnosis and treatment experience summarized to improve the understanding of coccidioidomycosis for clinical workers.
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