Study on the secondary metabolites of marine fungus Phaeospheriopsis sp.ZYX-Z-811
The secondary metabolites of marine fungus Phaeosporiopsis sp.ZYX-Z-811 were isolated and identified,and their biological activities were evaluated.The compounds were separated and purified by Silica gel,C18,Sephadex LH-20 column chromatography and high performance liquid chromatography(HPLC),ten compounds were separated,and their structures were identified by NMR,IR and UV spectroscopic methods.Ten compounds were identified as 4-epi-lignicol(1),lignicol(2),6-demethylkigelin(3),6,8-dihydroxy-3,4,7-trimethylisocoumarin(4),6,7-dimethoxymellein(5),musaone A(6),2-(4-hydroxyphenyl)ethylacetate(7),3-indole formaldehyde(8),indole-3-acetic acid methyl ester(9),methyl p-hydroxybenzoate(10),among which compound 1 was not published in journal,and the absolute configuration was determined by ECD calculation.These compounds were evaluated for antioxidant activity and α-glucosidase in hibitoryactivity,respectively,compound 10 showed weak antioxidant activities.
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