Study on the secondary metabolites from the Weizhou Island coral Acropora austera associated fungus Arachniotus ruber GXIMD 02510 and their antibacterial activity
The secondary metabolites and antibacterial activities of the Weizhou Island coral Acropora austera associated fungus Arachniotus ruber GXIMD 02510 were investigated.Various modern chromatographic techniques were used to isolate and purify the fermentation products of this strain.Their structures were determined by comprehensive spectroscopic methods,including nuclear magnetic resonance and by comparison with literature data.The antibacterial activity was determined.A total of 13 compounds were obtained and characterized,which were auxarthrols B,E,F,and H(1-4),paradictyoarthrin A(5),chrysoqueen(6),ocauxarthrol A(7),1,3,6-trihydroxy-8-methylxanthone(8),N-acetyltyramine(9),methyl 2-(4-hydroxyphenyl)acetate(10),m-hydroxylphenylacitic acid(11),L-tenuazonic acid(12),and 2,3,22,23-tertrahydroxy-2,6,10,15,19,23-hexamethyl-tetracosa-6,10,14,18-tetraene(13).Antibacterial activity test showed that compounds 1,4-6,and 11 showed inhibitory activity against Pseudomonas aeruginosa,and the minimum inhibitory concentration(MIC)values were ranging from 0.078 mg·mL-1 to 0.312 mg·mL-1.This study will expand the chemical diversity of the genus Arachniotus and also provide chemical entities for the development of antibiotics.
广西自然科学基金广西自然科学基金国家自然科学基金广西中医药大学第三批"岐黄工程"高层次人才团队培育项目桂派杏林青年英才项目High-Level Talent Training Project Foundation of Guangxi University of Chinese MedicineHigh-Level Talent Training Project Foundation of Guangxi University of Chinese Medicine
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